{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:11:49Z","timestamp":1771297909122,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010395","name":"HHV-6 Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CMV infection remains a significant cause of morbidity among pediatric HTx recipients We explored the implications of CMV infection on post\u2010transplant outcomes among CMV risk\u2010stratified pediatric HTx recipients receiving VGC prophylaxis. Children who underwent HTx between January 2010 and October 2016 were stratified according to CMV risk at time of transplant and evaluated for evidence of post\u2010transplant CMV infection, rejection, CAV, and graft loss. Among 97 children, 41 (42%) were considered HR or IR risk for CMV infection and received VGC prophylaxis. CMV DNAemia was observed in 34% of children, including 71% HR, 40% IR, and 18% LR individuals. Median time to CMV DNAemia following VGC prophylaxis was 32D among HR vs 277D in IR subjects (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.042). No difference\u00a0in overall graft loss was noted among groups, but CMV HR children had decreased rejection\u2010free survival (3.5\u00a0years) compared to IR (6\u00a0years,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.015) and LR children (8\u00a0years,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0003). CMV was noted on EMB in 13% of children but was not associated with increased CAV, rejection or graft loss. High\u2010risk CMV status was associated with decreased time to CMV infection despite VGC prophylaxis, compared to IR, and decreased rejection\u2010free survival times compared to both IR and LR recipients. Detection of CMV on EMB was not associated with increased rejection, CAV or graft loss. Additional studies are needed to explore the impact of CMV infection on rejection\u2010free survival in HTx recipients.<\/jats:p>","DOI":"10.1111\/petr.13750","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T14:12:09Z","timestamp":1592921529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cytomegalovirus infection and allograft rejection among pediatric heart transplant recipients in the era of valganciclovir prophylaxis"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9530-8785","authenticated-orcid":false,"given":"Bibhuti B.","family":"Das","sequence":"first","affiliation":[{"name":"Texas Children's Hospital Baylor College of Medicine Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7051-4670","authenticated-orcid":false,"given":"Bhupesh K.","family":"Prusty","sequence":"additional","affiliation":[{"name":"Institute for Virology and Immunobiology University of Wuerzburg Wuerzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianli","family":"Niu","sequence":"additional","affiliation":[{"name":"Office of Human Research Memorial Healthcare System Hollywood Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9750-9107","authenticated-orcid":false,"given":"Paul K.","family":"Sue","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13512"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002191"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000229039.87735.76"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328259c33b"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.03.015"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12896"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12868"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S36578"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2014.08.043"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.07.011"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12786"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/pis056"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/TP.0000000000001944","article-title":"Complement (C1q) binding de novo donor specific antibodies and cardiac allograft vasculopathy in pediatric heart transplant recipients","volume":"102","author":"Das BB","year":"2018","journal-title":"Transplantation"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.03.019"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03074.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ff1493"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"e13650","DOI":"10.1111\/petr.13650","article-title":"Burden of cytomegalovirus DNAemia among pediatric renal transplant patients on antiviral prophylaxis: a hospital\u2010based analysis","volume":"24","author":"Mehta K","year":"2019","journal-title":"Pediatr Transplant"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002115"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz181"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12417"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.3138"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.627570"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13015"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009111188"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1321-1"},{"issue":"11","key":"e_1_2_9_28_1","first-page":"II207","article-title":"Cytomegalovirus infection in heart transplant recipients is associated with impaired endothelial function","volume":"110","author":"Petrakopoulou P","year":"2004","journal-title":"Circulation"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000109692.16004.AF"},{"key":"e_1_2_9_30_1","first-page":"58","article-title":"Induction of endothelial adhesion molecules by rat cytomegalovirus in allogeneic lung transplantation in the rat","volume":"99","author":"Steinhoff G","year":"1995","journal-title":"Scand J Infect Dis Suppl"},{"key":"e_1_2_9_31_1","first-page":"1108","article-title":"Enhancement of cytomegalovirus infection and acute rejection after allogeneic lung transplantation in the rat: virus\u2010induced expression of major histocompatibility complex class II antigens","volume":"15","author":"You XM","year":"1996","journal-title":"J Heart Lung Transplant"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(02)01185-3"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13155"},{"issue":"1","key":"e_1_2_9_34_1","first-page":"8","article-title":"Indirect effects of CMV in the solid organ transplant patient","volume":"1","author":"Paya CV","year":"1999","journal-title":"Transpl Infect Dis"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105173442002"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2009.00478.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12030"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12179"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ffffd3"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13750","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13750","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.13750","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T20:53:25Z","timestamp":1696280005000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,23]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/petr.13750"],"URL":"https:\/\/doi.org\/10.1111\/petr.13750","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,23]]},"assertion":[{"value":"2019-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13750"}}