{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:39:35Z","timestamp":1753879175353,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Living donors (LDs) are preferred over DDs for renal transplantation in children due to superior GS. Oslo University Hospital has never restricted living donation by upper age. The aim of this study was to investigate long\u2010term outcomes using grandparents (GPLD) compared to PLD. Retrospective nationwide review in the period 1970\u20102017. First renal graft recipients using a GPLD were compared to PLD kidney recipients for long\u2010term renal function and GS. 278 children (\u226418\u00a0years) received a first renal transplant: 27\/251 recipients with a GPLD\/PLD. GPLD (median 59 (42\u201074)\u00a0years) were significantly older than PLD (median 41 (23\u201065)\u00a0years, (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Median DRAD was 52 (38\u201070) vs 28 (17\u201048)\u00a0years, respectively. GS from GPLD and PLD had a 1\u2010, 5\u2010, and 10\u2010year survival of 100%, 100%, and 90% vs 93%, 82%, and 72%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.6). In a multivariate Cox regression analysis adjusted for gender, donor age, recipient age, and year of transplant, this finding was similar (HR 0.98; 95% CI 0.34\u20102.84, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.97). Five\u2010year eGFR was 47.3 and 59.5\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> in the GPLD and PLD groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.028), respectively. In this nationwide retrospective analysis, GS for pediatric renal recipients using GPLD was comparable to PLD. Renal function assessed as eGFR was lower in the GPLD group. The GPLD group was significantly older than the PLD group, but overall this did not impact transplant outcome. Based on these findings, older age alone should not exclude grandparent donations.<\/jats:p>","DOI":"10.1111\/petr.13751","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T18:44:05Z","timestamp":1591123445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Five decades with grandparent donors: The Norwegian strategy and experience"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1421-0098","authenticated-orcid":false,"given":"Anna","family":"Bjerre","sequence":"first","affiliation":[{"name":"Department of Pediatrics Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geir","family":"Mj\u00f8en","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e5l\u2010Dag","family":"Line","sequence":"additional","affiliation":[{"name":"University of Oslo Oslo Norway"},{"name":"Department of Transplantation Medicine Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Naper","sequence":"additional","affiliation":[{"name":"Department of Immunology Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Varberg","family":"Reis\u00e6ter","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"Norwegian Renal Registry Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"\u00c5sberg","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"Norwegian Renal Registry Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"Department of Pharmacy University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2007.00896.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05021107"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2396-1"},{"issue":"5","key":"e_1_2_7_5_1","first-page":"349","article-title":"Grandparent donors in a living related renal transplant program","volume":"11","author":"Nyberg SL","year":"1997","journal-title":"Clin 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