{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:03:14Z","timestamp":1788397394218,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>SOT is the treatment of choice for end\u2010stage organ disease. Improved long\u2010term survival after NKSOT has uncovered chronic morbidity including CKD. AKI is common after NKSOT and may be associated with long\u2010term CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective cohort study looking at AKI and CKD after pediatric heart (n\u00a0=\u00a0109) or liver (n\u00a0=\u00a0112) transplant. AKI was defined using KDIGO creatinine\u2010based criteria. pAKI was AKI\u00a0\u2264\u00a07\u00a0days post\u2010transplant; CKD\n                      <jats:sub>3\u20105<\/jats:sub>\n                      was eGFR\u00a0&lt;\u00a060\u00a0mL\/min\/1.73\u00a0m\n                      <jats:sup>2<\/jats:sup>\n                      by modified Schwartz formula for &gt;\u00a03\u00a0months. We looked at the incidence of CKD\n                      <jats:sub>3\u20105<\/jats:sub>\n                      and the effect of perioperative pAKI on the slope of eGFR post\u2010transplant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      pAKI was seen in 63% (n\u00a0=\u00a069) after heart and 38% (n\u00a0=\u00a043) after liver transplant. pAKI was associated with longer ICU and hospital stays. Cumulative incidence (95% CI) of CKD\n                      <jats:sub>3\u20105<\/jats:sub>\n                      at 60\u00a0months post\u2010heart transplant was 40.9% (27.9%\u201057.1%) in patients with AKI vs 35.8% (17.1%\u201064.8%) in those without (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0NS). Post\u2010liver transplant, the cumulative incidence of CKD\n                      <jats:sub>3\u20105<\/jats:sub>\n                      at 60\u00a0months was 0% in those without pAKI vs 10% (3.2%\u201029.3%) in those with (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01). Patients with pAKI had lower eGFR at last follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>pAKI and CKD are common after NKSOT. Incidence of CKD is higher in those with pAKI. AKI episodes are associated with a drop in eGFR during follow\u2010up. Identifying patients who have had AKI is an important first step in identifying those at risk of repeated AKI episodes. These patients would benefit from closer monitoring for CKD, lower nephrotoxic drug use, and follow\u2010up with nephrology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.13753","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T12:43:59Z","timestamp":1591274639000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Acute kidney injury and chronic kidney disease after non\u2010kidney solid organ transplantation"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-0307","authenticated-orcid":false,"given":"Shina","family":"Menon","sequence":"first","affiliation":[{"name":"Division of Nephrology Seattle Children's Hospital  Seattle WA USA"},{"name":"Department of Pediatrics University of Washington School of Medicine  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari 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