{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:38:23Z","timestamp":1785893903087,"version":"3.56.0"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T00:00:00Z","timestamp":1601769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Almost half the children who undergo kidney transplantation (KTx) have congenital abnormalities of the kidney and urinary tract (CAKUT). We compared patient, graft survival, and kidney function at last follow\u2010up between CAKUT and non\u2010CAKUT patients after KTx. We divided the analysis into two eras: 1988\u20102000 and 2001\u20102019. Of 923 patients, 52% had CAKUT and 48% non\u2010CAKUT chronic kidney disease (CKD). Of the latter, 341 (77%) had glomerular disease, most frequently typical HUS (32%) and primary FSGS (27%); 102 had non\u2010glomerular disease. CAKUT patients were more often boys, younger at KTx, transplanted more frequently preemptively, but with longer time on chronic dialysis. They had less delayed graft function (DGF) and better eGFR, but higher incidence of urinary tract infection (1 year post\u2010KTx). In both eras, 1\u2010, 5\u2010, and 10\u2010year patient survival was similar in the groups, but graft survival was better in CAKUT recipients vs those with primary glomerular and primary recurrent glomerular disease: Era 1, 92.3%, 80.7%, and 63.6% vs 86.9%, 70.6%, and 49.5% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), and 76.7%, 56.6%, and 34% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0003); Era 2, 96.2%, 88%, and 73.5% vs 90.3%, 76.1%, and 61% (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0075) and 75.4%, 54%, and 25.2% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001), respectively. Main predictors of graft loss were DGF, late acute rejection (AR), and age at KTx in CAKUT group and disease relapse, DGF, early AR, and number of HLA mismatches in recipients with glomerular disease. Graft survival was better in CAKUT patients. DGF was the main predictor of graft loss in all groups. Disease recurrence and early AR predicted graft failure in patients with glomerular disease.<\/jats:p>","DOI":"10.1111\/petr.13763","type":"journal-article","created":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T17:30:21Z","timestamp":1601832621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Kidney transplantation in children with CAKUT and non\u2010CAKUT causes of chronic kidney disease: Do they have the same outcomes?"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-2066","authenticated-orcid":false,"given":"Marta Lidia","family":"Monteverde","sequence":"first","affiliation":[{"name":"Nephrology Unit Hospital de Pediatr\u00eda JP Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Paz","sequence":"additional","affiliation":[{"name":"Nephrology Unit Hospital de Pediatr\u00eda JP Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pedro","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Nephrology Unit Hospital de Pediatr\u00eda JP Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia Beatriz","family":"Chaparro","sequence":"additional","affiliation":[{"name":"Nephrology Unit Hospital de Pediatr\u00eda JP Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Solernou","sequence":"additional","affiliation":[{"name":"Pathology Unit Hospital de Pediatr\u00eda JP Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6884-8898","authenticated-orcid":false,"given":"Cristian","family":"Sager","sequence":"additional","affiliation":[{"name":"Urology Unit Hospital de Pediatr\u00eda JP Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Tessi","sequence":"additional","affiliation":[{"name":"Urology Unit Hospital de Pediatr\u00eda JP Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Locane","sequence":"additional","affiliation":[{"name":"Nephrology Unit Hospital de Pediatr\u00eda JP Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,4]]},"reference":[{"issue":"7","key":"e_1_2_8_2_1","first-page":"vii165","article-title":"Demography and management of childhood established renal failure in the UK (chapter 13)","volume":"22","author":"Lewis M","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.4.e382"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1181-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00467-009-1424-2","article-title":"Clinical characteristics, and outcomes of children with stage 3\u20135 chronic kidney disease","volume":"25","author":"Mong Hiep TT","year":"2010","journal-title":"Pediatr Nephrol"},{"key":"e_1_2_8_6_1","first-page":"552","article-title":"Comit\u00e9 Nacional de Nefrolog\u00eda. 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