{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T08:49:20Z","timestamp":1777798160876,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["NCCHD 30\u20102"],"award-info":[{"award-number":["NCCHD 30\u20102"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The strategy to eradicate polio is based on preventing infection by immunizing all children until the world is polio\u2010free. However, data regarding efficacy of polio\u2010containing vaccination in immunocompromised patients such as LT recipients are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an observational study at the largest pediatric transplant center in Japan from January 2011 to January 2015. LT recipients were enrolled after transplantation, and those who had completed the Japanese polio vaccination program were eligible for the study. Patients' demographics were collected from their medical records. Antibody titers against poliovirus serotypes 1\u20103 were measured using the neutralization test at the routine follow\u2010up visits after enrollment. Factors associated with seropositivity against each type of poliovirus were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010four patients who had received the complete polio vaccination series were enrolled in the study. Of these, 37 patients had received all series of polio\u2010containing vaccination before LT. Median age of the patients was 75\u00a0months. Their underlying diseases included the following: 40 (63%) with cholestatic liver diseases and 11 (17%) with metabolic disorders. After a median interval of 43\u00a0months after LT, seropositivity rates against poliovirus 1, 2, and 3 were 93.8% (60\/64), 92.2% (59\/64), and 54.7% (35\/64), respectively. Among 32 patients who had received only oral polio vaccine (OPV), seropositivity against poliovirus 3 was particularly low (25.0%). No factors associated with seropositivity against each type of poliovirus were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the LT recipients, seropositivity for poliovirus 3 was low, suggesting a need for additional inactivated polio\u2010containing vaccination after LT, especially for patients who had received only OPV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13766","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T18:29:33Z","timestamp":1592504973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serostatus following polio\u2010containing vaccination before and after liver transplantation"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6598-5187","authenticated-orcid":false,"given":"Takanori","family":"Funaki","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Medical Subspecialties National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4684-0446","authenticated-orcid":false,"given":"Akinari","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Transplant Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3031-7319","authenticated-orcid":false,"given":"Seisuke","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Transplant Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1651-0430","authenticated-orcid":false,"given":"Mureo","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Transplant Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2404-1128","authenticated-orcid":false,"given":"Akihiko","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Niigata University Graduate School of Medical and Dental Sciences Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3886-9089","authenticated-orcid":false,"given":"Isao","family":"Miyairi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medical Subspecialties National Center for Child Health and Development Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,18]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Global Polio Eradication Initiative. Polio eradication & endgame strategic plan 2013\u20102018.http:\/\/polioeradication.org\/wp\u2010content\/uploads\/2016\/07\/PEESP_EN_A4.pdf. Accessed August 13 2019."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.15.19"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu222"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.06.022"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60232-3"},{"key":"e_1_2_7_7_1","unstructured":"Global Polio Eradication Initiative.Polio Today.http:\/\/polioeradication.org\/polio\u2010today\/. Accessed August 13 2019."},{"key":"e_1_2_7_8_1","unstructured":"National Epidemiological Surveillance of Vaccine Preventable Diseases.https:\/\/www.niid.go.jp\/niid\/ja\/y\u2010graphs\/8126\u2010polio\u2010yosoku\u2010serum2017.html. Accessed March 13 2020. (only in Japanese)."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-013-0641-6"},{"key":"e_1_2_7_10_1","unstructured":"Ministry of Health Labour and Welfare.Question and Answer on Polio Vaccine.http:\/\/www.mhlw.go.jp\/bunya\/kenkou\/polio\/qa.html. Accessed August 13 2019."},{"key":"e_1_2_7_11_1","unstructured":"Japan Pediatric Society.Vaccination Schedule Recommended by the Japan Pediatric Society.https:\/\/www.jpeds.or.jp\/uploads\/files\/20180801_JPS%20Schedule%20English.pdf. Accessed August 13 2019."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24104"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.04.026"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.03.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12930"},{"key":"e_1_2_7_16_1","unstructured":"National Institute of Infectious Diseases.National Epidemiological Surveillance of Vaccine Preventable Diseases 2016. Age distribution of Polio NT antibody positives in Japan 2016https:\/\/www.niid.go.jp\/niid\/ja\/y\u2010graphs\/7173\u2010polio\u2010yosoku\u2010serum2016.html. Accessed August 13 2019."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit684"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199703270-00008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056974"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.08.032"},{"key":"e_1_2_7_21_1","unstructured":"Global Polio Eradication Initiative.Fact sheets \u2010Vaccine\u2010derived poliovirus.http:\/\/polioeradication.org\/wp\u2010content\/uploads\/2018\/07\/GPEI\u2010cVDPV\u2010Fact\u2010Sheet\u201020191115.pdf. Accessed March 13 2020."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6809a2"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.4.1285"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.13766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.13766","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T15:59:21Z","timestamp":1693929561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,18]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/petr.13766"],"URL":"https:\/\/doi.org\/10.1111\/petr.13766","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,18]]},"assertion":[{"value":"2020-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13766"}}