{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:50:00Z","timestamp":1787064600644,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diarrhea is a common problem in the pediatric post\u2010solid organ transplant and post\u2010hematopoietic stem cell transplant populations. Infectious etiology incidences are poorly defined, and the possibility of multi\u2010organism positivity is often uninvestigated. The aim of this study is to utilize stool multiplex GIP assays to compare the PTP and NTP regarding the incidence and profiles of single\u2010organism and multi\u2010organism infectious diarrhea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010center retrospective review was conducted, investigating stool multiplex GIP panel results over a more than 3\u2010year period, for pediatric patients. Assays test for 23 viral, bacterial, and protozoal organisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Positive assays in the PTP and NTP were 70\/101 (69.3%) and 962\/1716 (56.1%), respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.009). Thirty\u2010two percent (32\/101) of assays within the PTP were multi\u2010organism positive, significantly more than 14.8% (254\/1716) in the NTP (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.00001). There was no significant difference in the incidence of single\u2010organism positives, 37.6% (38\/101) in PTP and 41.3% (708\/1716) in the NTP. The PTP demonstrated a statistically significantly higher incidence of the following organisms within multi\u2010agent positive GIPs (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05 for each):\n                      <jats:italic>Clostridioides difficile<\/jats:italic>\n                      ,\n                      <jats:italic>Cryptosporidium<\/jats:italic>\n                      , EPEC, norovirus, and sapovirus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The pediatric PTP demonstrates higher incidence of positive GIPs, higher rate of multi\u2010organism positivity, and unique infectious organism incidence profiles. These data can provide a framework for understanding organism\u2010specific pathogenicity factors, assessing the clinical impact of enteric co\u2010infection, and understanding the utility of this testing modality in this unique population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.13771","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T07:35:05Z","timestamp":1594193705000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Multi\u2010organism gastrointestinal polymerase chain reaction positivity among pediatric transplant vs non\u2010transplant populations: A single\u2010center experience"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8595-1598","authenticated-orcid":false,"given":"John M.","family":"Stone","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology Hepatology and Nutrition 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