{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:03:42Z","timestamp":1790550222185,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Myeloablative conditioning before allogeneic HSCT during childhood exposes to serious long\u2010term complications, especially gonadal dysfunction. Pubertal issues are less described than other post\u2010HSCT sequelae in childhood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pubertal development and biological gonadal parameters were assessed in a retrospective monocentric cohort of prepubertal patients who underwent HSCT after myeloablative conditioning with TBI or busulfan between 1981 and 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010four patients (28 girls and 46 boys) were included. No spontaneous pubertal development was found in 50% of girls and 10% of boys (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), and delayed puberty or no spontaneous pubertal development was found in 57% of girls and 24% of boys (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.009). HRT was used in 82% of girls and 24% of boys (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). In univariate analysis, TBI conditioning (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.05), female sex (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), acute GVHD (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.05), extensive chronic GVHD (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.021), steroid treatment &gt;6\u00a0months (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.016), and malignant diseases (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.016) were associated with no spontaneous pubertal development, whereas TBI conditioning (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.003) and extensive chronic GVHD (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.005) were associated with delayed puberty. In multivariate analysis, factors independently associated with no spontaneous puberty onset were female sex (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001) and age &gt;10\u00a0years (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.033). Factors independently associated with delayed puberty were extensive chronic GVHD (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.041) and age &gt;10\u00a0years (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.031).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlighted the toxicity of MAC in prepubescent children: TBI did worse, but this was especially true for the most susceptible patients (girls, leukemic patients, and patients older than 10\u00a0years). It suggests a possible role of GVHD in delayed puberty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.13773","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T10:53:31Z","timestamp":1595501611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pubertal outcomes of children transplanted with allogeneic stem cells after myeloablative total body irradiation or busulfan: Influence of age and sex is confirmed, while a role of chronic graft\u2010versus\u2010host disease in delayed puberty onset is revealed"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1795-8904","authenticated-orcid":false,"given":"Sara","family":"Weinhard","sequence":"first","affiliation":[{"name":"D\u00e9partement d'Onco\u2010H\u00e9matologie P\u00e9diatrique CHRU de Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Wiedemann","sequence":"additional","affiliation":[{"name":"D\u00e9partement de R\u00e9animation p\u00e9diatrique CHRU de Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Leheup","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Infantile CHRU de Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Hugues","family":"Dalle","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Immuno\u2010H\u00e9matologie P\u00e9diatrique Assistance Publique des H\u00f4pitaux de Paris (AP\u2010HP) H\u00f4pital Universitaire Robert Debr\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Lebon Labich","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Infantile CHRU de Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Pochon","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Onco\u2010H\u00e9matologie P\u00e9diatrique CHRU de Nancy Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.04.015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.210"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.09.013"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2231"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bulcan.2015.04.005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-1-201107050-00004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-014-0162-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.10.006"},{"issue":"2","key":"e_1_2_8_10_1","first-page":"65","article-title":"Endocrine late effects of childhood cancer therapy: a report from the children\u2019s oncology group","volume":"69","author":"Nandagopal R","year":"2008","journal-title":"HRP"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-2265.2004.00165.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.9.1107"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701754"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705374"},{"key":"e_1_2_8_15_1","unstructured":"Bresters.Incidence and severity of crucial late effects after allogeneic HSCT for malignancy under the age of 3 years: TBI is what really matters | Bone Marrow Transplantation.https:\/\/www.nature.com\/articles\/bmt2016139. 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