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This meta\u2010analysis aims to identify the factors associated with better prognosis in these patients. Thirteen articles reporting 63 patients with major histocompatibility complex class II deficiency that underwent hematopoietic stem cell transplant were included. The median age for hematopoietic stem cell transplant was 18\u00a0months. The most common source of transplant was bone marrow, with alternative sources as umbilical cord blood emerging during recent years. The highest proportion of engraftment was seen with umbilical cord. Engraftment was higher in patients with matched donors, with better overall survival in patients with reduced\u2010intensity conditioning. Graft\u2010vs\u2010host disease developed in 65% of the patients, with grades I\u2010II being the most frequently encountered. There was a higher mortality in patients with myeloablative conditioning and no engraftment. There was an inverse correlation between survival and stage of graft\u2010vs\u2010host disease. The main cause of mortality was infectious disease, mostly secondary to viral infections. Ideally, matched grafts should be used, and reduced\u2010intensity conditioning should be considered to reduce early post\u2010transplant complications. GVHD and viral prophylaxis are fundamental.<\/jats:p>","DOI":"10.1111\/petr.13774","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T13:44:21Z","timestamp":1594993461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Meta\u2010analysis of hematopoietic stem cell transplantation in major histocompatibility complex class II deficiency"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-8401","authenticated-orcid":false,"given":"Lina Maria","family":"Castano\u2010Jaramillo","sequence":"first","affiliation":[{"name":"Facultad de Medicina Universidad CES Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2552-3660","authenticated-orcid":false,"given":"Jose","family":"Bare\u00f1o\u2010Silva","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Universidad CES 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