{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:07:22Z","timestamp":1782317242565,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>LT is a successful treatment for end\u2010stage liver disease. The long\u2010term outcome of patients transplanted in childhood has not previously been widely reported. This project assessed the long\u2010term impact of transplantation in patients surviving &gt;15\u00a0years. Retrospective data on growth, end\u2010organ damage and psychosocial development were collected in young people transplanted from 1985 to 2000 in a single centre. Clinical notes were reviewed, and patients interviewed at clinic follow\u2010up. 224 patients were transplanted between 1985 and 2000. 143 recipients (63.8%) survived &gt;15\u00a0years with a median survival of 19.52\u00a0years. The majority were well, and only 10% had abnormal graft function (biochemical\/synthetic), the main cause of which was chronic hepatitis (6%). Renal dysfunction and the necessity for renal transplant were identified in 32.8%, of whom 16.7% of patients had a cGFR &lt;70\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> and 6% of patients had either undergone or awaiting renal transplant. This cohort was healthier than the average age\u2010matched UK population in terms of body mass index (9% obese), smoking and alcohol consumption. 92% of patients had completed or were in education (93\/123 had completed education and 20\/123 remained in school). 63.7% of patients had been transitioned into adult services, and 46.3% of these patients were employed. 67.5% were in a relationship, one patient was divorced, and 10.6% of patients had one or more children. 11 patients had symptoms that corresponded to a DSM IV diagnosis of depression. Four patients had anorexia nervosa. Developmental delay was identified in 9 out of 99 patients. The development of malignancy, including PTLD, occurred in 10\/143 (7%) patients at a median time post\u2010transplant of 2.76\u00a0years (range 0.76\u20109.06\u00a0years). Epstein\u2010Barr infection was implicated in 75% of these malignancies. We conclude the long\u2010term outcome of LT in childhood is good with 63.8% surviving into adulthood and over 60% transferring into adult services. Graft dysfunction and end organ damage are minimal. Our cohort is healthier than the general population, and the majority have completed education, sought employment and formed relationships with peers, contributing well to society.<\/jats:p>","DOI":"10.1111\/petr.13782","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T14:58:39Z","timestamp":1594997919000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["What is the long\u2010term outlook for young people following liver transplant? A single\u2010centre retrospective analysis of physical and psychosocial outcomes"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7987-2180","authenticated-orcid":false,"given":"Nicola","family":"Ruth","sequence":"first","affiliation":[{"name":"The Liver Unit Birmingham Women's &amp; Children's Hospital Birmingham UK"},{"name":"University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Sharif","sequence":"additional","affiliation":[{"name":"The Liver Unit Birmingham Women's &amp; Children's Hospital Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Legarda","sequence":"additional","affiliation":[{"name":"The Liver Unit Birmingham Women's &amp; Children's Hospital Birmingham UK"},{"name":"Gastroenterologica Hepatologica y Nutricion pediatricas Hospital Universitano Cruces Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Smith","sequence":"additional","affiliation":[{"name":"The Liver Unit Birmingham Women's &amp; Children's Hospital Birmingham UK"},{"name":"Queen Elizabeth Hospital Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipa","family":"Lewis","sequence":"additional","affiliation":[{"name":"The Liver Unit Birmingham Women's &amp; Children's Hospital Birmingham UK"},{"name":"Queen Elizabeth Hospital Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Lloyd","sequence":"additional","affiliation":[{"name":"The Liver Unit Birmingham Women's &amp; Children's Hospital Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Mirza","sequence":"additional","affiliation":[{"name":"The Liver Unit Birmingham Women's &amp; Children's Hospital Birmingham UK"},{"name":"University of Birmingham Birmingham UK"},{"name":"Queen Elizabeth Hospital Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre","family":"Kelly","sequence":"additional","affiliation":[{"name":"The Liver Unit Birmingham Women's &amp; Children's Hospital Birmingham UK"},{"name":"University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196809000-00009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010124"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.648"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1363"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.10.038"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.05.024"},{"key":"e_1_2_7_8_1","unstructured":"RCPCH(2013).\"UK CPCM growth chart. 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