{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:20:48Z","timestamp":1762543248631,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anemia is common but under\u2010diagnosed and often inadequately treated in KTX recipients. ID is the major cause of early\u2010onset anemia. We introduced routine use of parenteral (IV) iron in patients (2\u201018\u00a0years) who had KTX between January 2011 and December 2015. We explored the clinical benefits of this practice by comparing the iron\u2010treated subjects [TX] with historical controls who had KTX between 2005 and 2010. The prevalence of anemia at 6\u00a0months (early\u2010onset) for the cohort (both the study group and controls) was 55% and for anemia at 12\u00a0months (late\u2010onset) was 60%. Although cause\u2010effect relationship may not be proven in a retrospective study design, there was a significant greater frequency of ID and anemia at 3 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.02) and 6\u00a0months (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.04), and a reduced allograft function (eGFR\u00a0&lt;\u00a060\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>) at 12 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03) and 24\u00a0months (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04) of KTX in the control arm. Furthermore, a greater proportion of the control arm required either ESA (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03) or blood transfusion (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04) as a rescue treatment for moderate\u2010to\u2010severe anemia. In conclusion, routine parenteral iron treatment was associated with a lower prevalence of early\u2010 and late\u2010onset anemia, and a lower requirement for either ESA rescue or blood transfusion.<\/jats:p>","DOI":"10.1111\/petr.13787","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T15:19:32Z","timestamp":1594999172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of immediate post\u2010transplant parenteral iron therapy on the prevalence of anemia and short\u2010term allograft function in a cohort of pediatric and adolescent renal transplant recipients"],"prefix":"10.1111","volume":"24","author":[{"given":"Franca","family":"Iorember","sequence":"first","affiliation":[{"name":"Division of Pediatric Nephrology Phoenix Children's Hospital Phoenix Arizona 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