{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:10:56Z","timestamp":1758633056143,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["234\u20102005\u201037011C"],"award-info":[{"award-number":["234\u20102005\u201037011C"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Under the current kidney allocation system, pediatric candidates listed prior to age 18 receive priority for high\u2010quality deceased donor organs. This has resulted in a decline in living donor transplantation in pediatrics, despite superior outcomes of living donor transplantation. Due to a young age at transplantation, most pediatric kidney transplant recipients require re\u2010transplantation. The effects of a previously failed deceased donor vs a previously failed living donor on re\u2010transplant candidates are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the United Network for Organ Sharing database, we examined 2772 re\u2010transplant recipients aged 18\u201030\u00a0years at time of relisting for second KT from 2000 to 2018 with history of prior pediatric KT (age\u00a0\u2264\u00a018\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PFLDKT recipients compared to those with PFDDKT had shorter median waiting times and dialysis time regardless of their second donor type (14.0 vs 20.3\u00a0months, and 19.1 vs 34.5\u00a0months, respectively). PFLDKT recipients had higher re\u2010transplant rates (adjusted HR 1.17, 95% CI 1.09\u20101.27, and adjusted HR 1.05, 95% CI 0.95\u20101.15 when calculating from time of relisting and time of returning to dialysis, respectively). PFDDKT recipients were more likely to have higher median PRA levels (90% vs 73%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Re\u2010transplant candidates who received a previous deceased donor as a child had a higher level of sensitization, longer waiting time, and dialysis exposure compared to those with PFLDKT. Among primary pediatric kidney transplant candidates, consideration should be considered for living donor transplantation, despite the priority for deceased donor organs, to avoid increased sensitization and longer waiting times for with re\u2010transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13800","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:28:06Z","timestamp":1595982486000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Time to second kidney transplantation in young adults after failed pediatric kidney transplant"],"prefix":"10.1111","volume":"24","author":[{"given":"Korntip","family":"Phonphok","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Medicine Kidney and Pancreas Transplant Research Center David Geffen School of Medicine at UCLA Los Angeles CA USA"},{"name":"Division of Nephrology Department of Medicine Rajavithi Hospital Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6846-2100","authenticated-orcid":false,"given":"Piyavadee","family":"Homkrailas","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Kidney and Pancreas Transplant Research Center David Geffen School of Medicine at UCLA Los Angeles CA USA"},{"name":"Division of Nephrology Department of Medicine Bhumibol Adulyadej Hospital Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tin","family":"Duong","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Kidney and Pancreas Transplant Research Center David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunee","family":"Panombualert","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology Department of Pediatrics Khon Kaen University Khon Kaen Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong W.","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Kidney and Pancreas Transplant Research Center David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Kidney and Pancreas Transplant Research Center David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik L.","family":"Lum","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Kidney and Pancreas Transplant Research Center David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1668-2005","authenticated-orcid":false,"given":"Suphamai","family":"Bunnapradist","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Kidney and Pancreas Transplant Research Center David Geffen School of Medicine at UCLA Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2313-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031643"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2018.00205"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12859"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12883"},{"key":"e_1_2_9_7_1","first-page":"57","article-title":"Organ retransplantation in the United States: trends and implications","author":"Rao PS","year":"2008","journal-title":"Clin Transpl"},{"key":"e_1_2_9_8_1","unstructured":"National Data \u2010 OPTN Waiting List Additions Listing Year by Diagnosis.https:\/\/optn.transplant.hrsa.gov\/data\/view\u2010data\u2010reports\/national\u2010data\/. Accessed February 9 2018"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01786.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199812270-00014"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000235434.13327.11"},{"key":"e_1_2_9_12_1","unstructured":"The 2017 USRDS Annual Data Report.https:\/\/www.usrds.org\/adr.aspx. Accessed February 20 2018"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12690"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31828c6d64"},{"key":"e_1_2_9_15_1","unstructured":"NAPRTCS 2014 Annual Transplant Report.https:\/\/web.emmes.com\/study\/ped\/annlrept\/annualrept2014.pdf. 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