{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T02:44:23Z","timestamp":1787453063824,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Historically, the IDSA and the AST have recommended that live vaccines not be administered post\u2010transplant due to concern for induction of vaccine\u2010strain disease in immunocompromised hosts. However, recent prospective studies and revised AST guidelines published in April 2019 suggest that in the current era of immunosuppression minimization, live vaccines may be safely administered to select transplant recipients with resulting immunoprotection. The goal of this study was to assess current post\u2010transplant live vaccine practices at individual pediatric liver transplant centers following the updated AST guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A six\u2010item email survey detailing center\u2010specific post\u2010transplant live vaccine practices followed by up to three response\u2010specific questions were distributed between July 2019 and May 2020 to a representative from each center participating in the SPLIT consortium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall survey response rate was 93% (41\/44 centers). Only 29% (12\/41) of centers offer live vaccines post\u2010transplant; each of these 12 centers uses different eligibility criteria for live vaccines. There was no difference between large (ten or more transplants per year) and small (less than ten transplants per year) centers in likelihood to offer live vaccines post\u2010transplant. The main reasons for a center not offering post\u2010transplant live vaccines were safety concerns and inability to reach group consensus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The majority of pediatric liver transplant centers are reluctant to offer live vaccines post\u2010transplant despite the updated AST guidelines. Prospective multicenter studies are needed to confirm safety and immunogenicity of live vaccines post\u2010transplant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.13804","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T13:29:11Z","timestamp":1599053351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A community divided: Post\u2010transplant live vaccine practices among Society of Pediatric Liver Transplantation (SPLIT) centers"],"prefix":"10.1111","volume":"24","author":[{"given":"Sarah","family":"Kemme","sequence":"first","affiliation":[{"name":"Section of Gastroenterology, Hepatology and Nutrition Digestive Health Institute Children's Hospital Colorado University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha S.","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Hepatology and Nutrition Digestive Health Institute Children's Hospital Colorado University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna J.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Section of Pediatric Infectious Diseases Children's Hospital Colorado University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Lobritto","sequence":"additional","affiliation":[{"name":"Center for Liver Disease and Transplantation NY Presbyterian\u2010Columbia Children's Hospital of New York New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-2552","authenticated-orcid":false,"given":"Saeed","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4021-5615","authenticated-orcid":false,"given":"Amy G.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Hepatology and Nutrition Digestive Health Institute Children's Hospital Colorado University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit684"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12122"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.01.048"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81545-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200208270-00020"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00403.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15101"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04273.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01210.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.01.075"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.11.052"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002866"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13571"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13563"},{"key":"e_1_2_8_16_1","unstructured":"Measles Cases and Outbreaks.Centers for Disease Control and Prevention.https:\/\/www.cdc.gov\/measles\/cases\u2010outbreaks.html. 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