{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:39:40Z","timestamp":1753879180237,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IL\u201010R deficiency results in severe immune dysregulation. Herein, we describe the successful treatment of a girl aged 6.8\u00a0years with IL10R deficiency by using RIC prior to HSCT from a matched unrelated donor. The regimen was well tolerated, the engraftment was completely attained. On a follow\u2010up of 7\u00a0months, the patient remained in good medical conditions with full donor chimerism. All complications before HSCT were completely resolved and her growth was accelerated. RIC regimen might be adequate to induce permanent engraftment and avoid severe organ toxicity in IL\u201010R deficiency patients.<\/jats:p>","DOI":"10.1111\/petr.13819","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T17:29:11Z","timestamp":1599067751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fludarabine\u2010based reduced\u2010intensity conditioning regimen for hematopoietic stem cell transplantation in pediatric patient with IL10 receptor deficiency"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3837-9549","authenticated-orcid":false,"given":"Maged","family":"Kheder","sequence":"first","affiliation":[{"name":"Pediatric Cell Therapy Research Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Pediatric Stem Cell Transplant Department Children\u2019s Hospital Damascus University Damascus 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