{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:15:37Z","timestamp":1773328537315,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psychiatric disorders are common in pediatric HTx recipients. However, the impact of psychiatric comorbidities on patient outcomes is unknown. We aimed to assess the impact of disorders of adjustment, depression, and anxiety on HTx outcomes in children; hypothesizing that the presence of psychiatric disorders during or preceding HTx would negatively impact outcomes. All pediatric HTx recipients \u22658\u00a0years of age who survived to hospital discharge were identified from a novel linkage between the PHIS and SRTR databases (2002\u20102016). Psychiatric disorders were identified using ICD codes during or preceding the HTx admission. Post\u2010transplant graft survival, freedom from readmission, and freedom from rejection were analyzed using the Kaplan\u2010Meier method. Multivariable Cox proportional hazard models were used to adjust for covariates. A total of 1192 patients were included, of which 133 (11.2%) had depression, 197 (16.5%) had anxiety, and 218 (18.3%) had adjustment disorders. The presence of depression was independently associated with higher rates of readmission (60.9% vs 54.1% at 6\u00a0months) (AHR 1.63, 95% CI 1.22\u20102.18, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) and inferior graft survival (70.2% vs 83.4% at 5\u00a0years) (AHR 1.62, 95% CI 1.14\u20102.3, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.007). Anxiety was independently associated with higher rates of readmission (60.4% vs 53.9% at 6\u00a0months) (AHR 1.46, 95% CI 1.09\u20101.94, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). Anxiety and depression in the pretransplant period are independently associated with outcomes following HTx in children. Evaluation and management of psychiatric comorbidities represents an important component of care in this vulnerable population.<\/jats:p>","DOI":"10.1111\/petr.13847","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T20:02:01Z","timestamp":1601496121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The impact of psychiatric disorders on outcomes following heart transplantation in children"],"prefix":"10.1111","volume":"24","author":[{"given":"Kia","family":"Quinlan","sequence":"first","affiliation":[{"name":"Vanderbilt University School of Medicine  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2341-0913","authenticated-orcid":false,"given":"Scott","family":"Auerbach","sequence":"additional","affiliation":[{"name":"Pediatrics Division of Cardiology Denver Anschutz Medical Campus Children's Hospital of Colorado University of Colorado  Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1325-4814","authenticated-orcid":false,"given":"David W.","family":"Bearl","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Monroe Carell Jr. Children's Hospital  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra A.","family":"Dodd","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Monroe Carell Jr. Children's Hospital  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cary W.","family":"Thurm","sequence":"additional","affiliation":[{"name":"Children's Hospital Association  Lenexa KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt","family":"Hall","sequence":"additional","affiliation":[{"name":"Children's Hospital Association  Lenexa KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dickey Catherine","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Child and Adolescent Psychiatry Vanderbilt University Medical Center  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7816-9928","authenticated-orcid":false,"given":"Andrea Nicole","family":"Lambert","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Monroe Carell Jr. Children's Hospital  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7068-0625","authenticated-orcid":false,"given":"Justin","family":"Godown","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Monroe Carell Jr. Children's Hospital  Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.10.022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13188"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00554.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2000.00110.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1397-3142.2003.00117.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsl046"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-016-0800-3"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000314548"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000901"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000438212.72960.ae"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-017-0626-0"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165517"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.47.3.213"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000824"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2016.04.002"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.132996"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2017.08.014"},{"key":"e_1_2_10_19_1","unstructured":"Pediatric Health Information System."},{"key":"e_1_2_10_20_1","unstructured":"Pediatric Antidepressant Dosing Chart. 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