{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:45:53Z","timestamp":1790444753064,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CART therapy is an approved therapy in advanced ALL. The mechanism of relapse post\u2010CART therapy is under vigorous research. We report a 9\u2010year\u2010old boy who received CD19\u2010CART therapy after BM ALL relapse post\u2010HSCT. He presented with unilateral eye swelling which was initially managed as orbital cellulitis. Later on, it was proven to be an isolated ALL orbital relapse without peripheral blood B\u2010cell detection or BM involvement. Despite radiotherapy, he subsequently developed refractory CD19 positive ALL BM relapse. This case highlights the possibility of unusual relapse sites after CART\u2010therapy and that regular peripheral B\u2010cell monitoring is not enough to assure remission status. Better monitoring tools are needed to detect early disease relapse. Further understanding of the pathophysiology of isolated extramedullary relapse post\u2010CART therapy is warranted to improve the management of such challenging presentations.<\/jats:p>","DOI":"10.1111\/petr.13852","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T19:54:23Z","timestamp":1601495663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Orbital extramedullary leukemia relapse in a pediatric patient post\u2010CART cell therapy\u2014Case report"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4860-0796","authenticated-orcid":false,"given":"Mohammed F.","family":"Essa","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology King Abdullah Specialist Children's Hospital Ministry of National Guard Health Affairs  Riyadh Saudi Arabia"},{"name":"College of Medicine King Saud bin Abdulaziz University for 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