{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T01:40:16Z","timestamp":1779154816651,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Post\u2010transplant lymphoproliferative disorders (PTLD) are a group of lesions that can complicate solid organ or hematopoietic stem cell transplantation and are often associated with Epstein\u2010Barr virus (EBV). The treatment of PTLD is dependent on the type of lesion and includes a wide range of therapies, but chimeric antigen receptor (CAR) T\u2010cell therapy has not previously been reported as a treatment option for PTLD. We present a patient who developed refractory PTLD in her right retroperitoneum, right inguinal and iliac chains, and right axillary region shortly after heart transplantation and was treated with CAR T\u2010cell therapy. She could not tolerate complete discontinuation of immunosuppression due to the risk of rejection of a life\u2010supporting graft. The patient's PTLD responded to CAR T\u2010cell therapy, and her heart was monitored throughout the treatment course without any signs of rejection or ventricular dysfunction. CAR T\u2010cell therapy may be a viable treatment option in patients who develop PTLD after a solid organ transplant.<\/jats:p>","DOI":"10.1111\/petr.13861","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T17:20:06Z","timestamp":1601572806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Treatment of post\u2010transplant lymphoproliferative disorder (PTLD) in a heart transplant recipient with chimeric antigen receptor T\u2010cell therapy"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0775-4572","authenticated-orcid":false,"given":"Brian N.","family":"Dang","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology and Oncology University of California Los Angeles David Geffen School of Medicine Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Ch\u2019ng","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology University of California Los Angeles David Geffen School of Medicine Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0291-7379","authenticated-orcid":false,"given":"Matthew","family":"Russell","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology University of California Los Angeles David Geffen School of Medicine Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry C.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Southern California Kaiser Permanente Medical Group Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7909-610X","authenticated-orcid":false,"given":"Theodore B.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology and Oncology University of California Los Angeles David Geffen School of Medicine Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Alejos","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology University of California Los Angeles David Geffen School of Medicine Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199911270-00015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/814973"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04197.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03387.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04206.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.69.3564"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931101)72:9<2782::AID-CNCR2820720941>3.0.CO;2-H"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1385\/MO:21:3:273"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10595"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.111"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201019666180418095526"},{"key":"e_1_2_7_15_1","unstructured":"U.S. Food & Drug Administration.FDA approves tisagenlecleucel for B\u2010cell ALL and tocilizumab for cytokine release syndrome. fda.govhttps:\/\/www.fda.gov\/drugs\/resources\u2010information\u2010approved\u2010drugs\/fda\u2010approves\u2010tisagenlecleucel\u2010b\u2010cell\u2010all\u2010and\u2010tocilizumab\u2010cy. 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