{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:41:52Z","timestamp":1761745312819,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe the successful pediatric liver transplant for unresectable hepatoblastoma in a 4\u2010year\u2010old male with COVID\u201019 prior to transplant. The first negative NP swab was documented 1\u00a0month after initial diagnosis, when SARS\u2010CoV\u20102 antibodies were also detected. The patient was actively listed for liver transplant after completing four blocks of a SIOPEL\u20104 based regimen due to his PRETEXT IV disease which remained unresectable. Following three additional negative NP swabs and resolution of symptoms for 4\u00a0weeks, he underwent a whole\u2010organ pediatric liver transplant. COVID\u201019 positivity determined via NP swab SARS\u2010CoV\u20102 real\u2010time RT\u2010PCR (Hologic Aptima SARS\u2010CoV\u20102 RT\u2010PCR assay). IgG and IgM total SARS\u2010 CoV\u20102 antibodies detected by Ortho Clinical Diagnostics VITROS\u00ae Immunodiagnostics Products Anti\u2010SARS\u2010CoV\u20102 Test. Patient received standard prednisone and tacrolimus\u2010based immunosuppression without induction therapy following transplant. Post\u2010transplant course was remarkable for neutropenia and thrombocytopenia, with discharge home on post\u2010transplant day #11. Surveillance tests have remained negative with persistent SARS\u2010CoV\u20102 IgG antibodies at 6\u00a0weeks after transplant. We describe one of the earliest, if not the first case of liver transplant following recent recovery from COVID\u201019 in a pediatric patient with a lethal malignant liver tumor. A better understanding of how to balance the risk profile of transplant in the setting of COVID\u201019 with disease progression if transplant is not performed is needed. We followed existing ASTS guidelines to document clearance of the viral infection and resolution of symptoms before transplant. This case highlights that pediatric liver transplantation can be safely performed upon clearance of COVID\u201019.<\/jats:p>","DOI":"10.1111\/petr.13880","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T10:56:20Z","timestamp":1601117780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Liver transplant in a recently COVID\u201019 positive child with hepatoblastoma"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4663-0086","authenticated-orcid":false,"given":"Matthew B.","family":"Goss","sequence":"first","affiliation":[{"name":"McGovern Medical School University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flor M.","family":"Munoz","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Pediatrics Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenly","family":"Ruan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Thao N.","family":"Galv\u00e1n","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation Department of Surgery Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine A.","family":"O'Mahony","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation Department of Surgery Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-0598","authenticated-orcid":false,"given":"Abbas","family":"Rana","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation Department of Surgery Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald T.","family":"Cotton","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation Department of Surgery Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8661-676X","authenticated-orcid":false,"given":"Nicolas F.","family":"Moreno","sequence":"additional","affiliation":[{"name":"McGovern Medical School University of Texas Health Science Center at Houston  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andras A.","family":"Heczey","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Pediatrics Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"Leung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition Department of Pediatrics Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Goss","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation Department of Surgery Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"issue":"5","key":"e_1_2_8_2_1","first-page":"796","article-title":"Cellular immune therapy for viral infections in transplant patients","volume":"138","author":"Khanna R","year":"2013","journal-title":"Indian J Med Res"},{"journal-title":"Am J Transpl","article-title":"Donor and transplant candidate selection for solid organ transplantation during the COVID\u201019 pandemic","author":"Galv\u00e1n NTN","key":"e_1_2_8_3_1"},{"volume-title":"COVID 19 Strike Force Guidance to Members on the Evolving Pandemic","year":"2020","author":"ASTS","key":"e_1_2_8_4_1"},{"volume-title":"Organ Retrieval for Transplantation in the COVID\u201019 Era","year":"2020","key":"e_1_2_8_5_1"},{"volume-title":"Clinical Best Practice Advice for Hepatology and Liver Transplant Providers during the 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