{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:10:30Z","timestamp":1761419430452,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sleep\u2010disordered breathing is commonly found in adults with heart failure both before and after HTx. Untreated sleep\u2010disordered breathing post\u2010transplant has been linked to late graft dysfunction, reduced quality of life, and increased morbidity. Sleep\u2010disordered breathing has not been investigated in pediatric HTx recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted retrospective review of patients &lt;21yo who underwent primary HTx at our center from 2009 to 2019 to describe clinical characteristics, cardiac history, and PSG results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and fifty patients were included; 60% had congenital heart disease, and 40% had cardiomyopathy. Fifty patients had PSG performed at median age of 6.1\u00a0years. Forty\u2010one were referred for symptoms of sleep\u2010disordered breathing. Obstructive sleep apnea was diagnosed in 45 patients and central sleep apnea in 3 patients. Of those with first PSG post\u2010transplant (n\u00a0=\u00a036), median AHI was 9.1\/h, and 19 (53%) were diagnosed with moderate or severe sleep apnea. Patients diagnosed with obstructive sleep apnea on PSG had more post\u2010transplant ventilator days (median 3 vs 2\u00a0days, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) and longer post\u2010transplant lengths of stay (median 28 vs 22\u00a0days, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this single\u2010center cohort of pediatric HTx recipients, sleep\u2010disordered breathing was common and associated with longer peri\u2010transplant respiratory support and length of stay. Given the high incidence of moderate and severe OSA detected in this population, clinicians should regularly screen for SDB and consider PSG testing more frequently in children who have undergone HTx. Further study into the long\u2010term impact of sleep\u2010disordered breathing in pediatric HTx recipients is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13888","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T23:41:26Z","timestamp":1603755686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sleep\u2010disordered breathing in pediatric heart transplant recipients"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1555-1425","authenticated-orcid":false,"given":"Weston T.","family":"Powell","sequence":"first","affiliation":[{"name":"Sleep and Pulmonary Medicine Seattle Children's Hospital University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maida","family":"Chen","sequence":"additional","affiliation":[{"name":"Sleep and Pulmonary Medicine Seattle Children's Hospital University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Kraft","sequence":"additional","affiliation":[{"name":"University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3072-4195","authenticated-orcid":false,"given":"Erin","family":"Albers","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Seattle Children's Hospital Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.3514"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.71"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.106.6.1689"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(03)00655-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2013.04.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192628"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.4.1288"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(00)00067-X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.06.076"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2003.10.032"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.04.005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.186.6.569a"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.4.1090"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-829631"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(97)00315-1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200708-135MG"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2016.07.002"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1671"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030888"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.696823"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2008.03.002"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139142"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3312"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1677"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617716000643"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201510-2099OC"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.03.021"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7334"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4698756"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-015-1269-3"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.01.019"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.2172"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-98141-3"},{"key":"e_1_2_7_37_1","unstructured":"R: The R Project for Statistical Computing.https:\/\/www.r\u2010project.org\/. 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