{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:50:16Z","timestamp":1781117416228,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is generally accepted that patients who have greater functional capacity are better candidates for lung transplantation. Accurate assessment of physical condition is important in identifying appropriate candidates for transplant. The focus of this study was to determine which measures of pretransplant physical condition correlate with positive post\u2010transplant outcomes in children undergoing lung transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was done on 44 patients, ages 5 to 21\u00a0years. The pretransplant data collected included functional status, 6MWT, ambulatory status, and mechanical support. Post\u2010transplant outcome data included time on the ventilator, days in the ICU, length of hospitalization, and 12\u2010month survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results were analyzed using Fisher exact and Kruskal\u2010Wallis tests. Patients with limited ambulation had more days in the ICU compared to the most ambulatory group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.043). Patients independent or needing some help with ADL had less time on the ventilator compared to patients needing total help. (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.014). Patients with 6MWT result greater than 500\u2019 had fewer ICU days (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.044) and marginally better 12\u2010month survival (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.057). The 12\u2010month survival of children needing invasive ventilatory support pretransplant was not significantly worse than those who did not; however, they required significantly more time on the ventilator (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.004), days in ICU (<jats:italic>P\u00a0<\/jats:italic>=\u00a0.013), and longer hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study demonstrated that pretransplant physical condition affects post\u2010transplant outcomes in children. Measures associated with positive post\u2010transplant outcomes were identified and could be beneficial in determining which patients are optimal candidates for lung transplant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13889","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:10:35Z","timestamp":1603930235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pediatric lung transplant: Correlation of pretransplant condition with post\u2010transplant outcomes"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7720-6969","authenticated-orcid":false,"given":"Dawn","family":"Freiberger","sequence":"first","affiliation":[{"name":"Division of Pulmonary Medicine Pediatric Transplant Center Boston Children's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Gould Delaney","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Pediatric Transplant Center Boston Children's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Forbes","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Pediatric Transplant Center Boston Children's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Manley","sequence":"additional","affiliation":[{"name":"Division of Pediatric Allergy and Pulmonary St. Louis Children's Hospital Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Visner","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine Pediatric Transplant Center Boston Children's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.08.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.04.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v6.i3.517"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.06.014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-520OC"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(02)00145-5"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01437.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02264.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201409-1698OC"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12010"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.11.597"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.04.012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.12.022"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.02155"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2011.07.009"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2016.1168298"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23535"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.12.052"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.123653"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200607-883OC"},{"key":"e_1_2_9_23_1","unstructured":"OPTN policy 10: allocation of lungs.https:\/\/optn.transplant.hrsa.gov\/resources\/by\u2010organ\/heart\u2010lung\/. 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