{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T21:33:57Z","timestamp":1781991237327,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T00:00:00Z","timestamp":1607212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dapsone has been utilized for the prevention of Pneumocystis jirovecii pneumonia in immunosuppressed patients including pediatric kidney transplant recipients, in whom trimethoprim\u2010sulfamethoxazole (TMP\u2010SMX) is contraindicated. Dapsone adverse effects include methemoglobinemia, but there are no reports of the burden and impact of methemoglobinemia in pediatric kidney recipients that are taking dapsone for PJP prophylaxis. We conducted a retrospective chart review of all pediatric kidney recipients who had received dapsone at any time posttransplant. The indication, duration, and adverse effects of dapsone therapy were assessed. In addition, methemoglobin levels were assessed, and summary statistics performed. Data demonstrated that more than half of the patients on dapsone were not screened for methemoglobinemia. Of those screened, there was a significantly higher acquired\u2010methemoglobinemia (77%) than previously reported in the literature. We also demonstrate significantly more anemia in patients on dapsone. Methemoglobinemia did not affect patient or graft survival and resolved with cessation of dapsone. We conclude that pediatric kidney recipients often develop methemoglobinemia and \/ or anemia on dapsone. We recommend if pediatric transplant recipients are prescribed dapsone, routine testing for methemoglobinemia and anemia should be done.<\/jats:p>","DOI":"10.1111\/petr.13921","type":"journal-article","created":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T09:05:45Z","timestamp":1607245545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dapsone\u2010induced methemoglobinemia in pediatrics post\u2010renal transplant"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9658-1951","authenticated-orcid":false,"given":"Aditi","family":"Hindka","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Pediatrics University of Minnesota Minneapolis MN USA"},{"name":"Alabama College of Osteopathic Medicine Dothan AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao","family":"Huynh","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Pediatrics University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8836-0881","authenticated-orcid":false,"given":"Priya S.","family":"Verghese","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine Chicago IL USA"},{"name":"Ann &amp; Robert H. Lurie Children's Hospital of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12291"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.07.025"},{"issue":"10","key":"e_1_2_9_4_1","first-page":"CD005590","article-title":"Prophylaxis for Pneumocystis pneumonia (PCP) in non\u2010HIV immunocompromised patients","volume":"2014","author":"Stern A","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.04.011"},{"key":"e_1_2_9_6_1","first-page":"123","article-title":"Management of Pneumocystis jirovecii pneumonia in HIV infected patients: current options, challenges and future directions","volume":"2","author":"Castro J","year":"2010","journal-title":"HIV AIDS 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