{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:20:51Z","timestamp":1788970851884,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We examined the association between induction type and outcomes of live\u2010donor pediatric kidney recipients on tacrolimus and mycophenolate maintenance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We analyzed the SRTR standard analysis file to evaluate primary live\u2010donor pediatric kidney recipients between 2000 and 2018. Recipients were grouped by induction type into three groups: alemtuzumab n\u00a0=\u00a0289, anti\u2010thymocyte n\u00a0=\u00a01197, and IL\u20102RA n\u00a0=\u00a01625. Kaplan\u2010Meier curves were generated for recipient and death\u2010censored graft survival. Predictors of recipient and allograft survival were examined using Cox proportional hazards models. Models were adjusted for age, sex, ethnicity, renal failure etiology, HLA\u2010mismatches, transplant year, steroid maintenance, preemptive transplantation, payor type, and donor factors such as age, sex, and donor\u2010recipient relationship. The transplant center was included as a random effect to account for inter\u2010center variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rejection rates at 6\u00a0months (Alemtuzumab 9.5% vs. r\u2010ATG 5.7% vs. IL2\u2010RA 5.3%; <jats:italic>P<\/jats:italic>: .023) and 12\u00a0months (Alemtuzumab 14.5% vs. r\u2010ATG 10.8% vs. IL2\u2010RA 9%; <jats:italic>P<\/jats:italic>: .028) were significantly higher in the alemtuzumab group. PTLD rate (Alemtuzumab 0.8% vs. r\u2010ATG 2.2% vs. IL2\u2010RA 1%; <jats:italic>P<\/jats:italic>: .028) was significantly higher in the anti\u2010thymocyte group. In the multivariable models, induction type did not influence patient or death\u2010censored graft survival within ten years post\u2010transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this large cohort of standard immunological risk primary pediatric live\u2010donor kidney recipients, as compared to IL\u20102RA, neither alemtuzumab nor anti\u2010thymocyte globulin was associated with improved long\u2010term graft or recipient survival. In the first year post\u2010transplant, recipients of alemtuzumab induction had a higher rejection rate, while PTLD was more frequently observed in the anti\u2010thymocyte recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13925","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T14:10:29Z","timestamp":1608300629000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Primary pediatric live\u2010donor\u2010kidney transplant\u2010recipients' outcomes by immunosuppression induction received in the United States"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5737-9742","authenticated-orcid":false,"given":"Samy","family":"Riad","sequence":"first","affiliation":[{"name":"Division of Renal Diseases and Hypertension Department of Medicine University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0062-3131","authenticated-orcid":false,"given":"Scott","family":"Jackson","sequence":"additional","affiliation":[{"name":"Complex Care Analytics MHealth Fairview Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5443-1258","authenticated-orcid":false,"given":"Srinath","family":"Chinnakotla","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8836-0881","authenticated-orcid":false,"given":"Priya","family":"Verghese","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology Ann &amp; Robert H. Lurie Children's Hospital Chicago IL USA"},{"name":"Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01335.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15274"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001577"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01780.x"},{"issue":"3","key":"e_1_2_11_6_1","first-page":"116","article-title":"Kidney transplantation in pediatric patients: 18\u2010year experience at Hotel\u2010Dieu de France","volume":"63","author":"Mourani C","year":"2015","journal-title":"J Med Liban"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00303.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01367.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318188af15"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-002-0942-y"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00509.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12374"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12048"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12089"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.07.050"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00879.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-6143.2003.00325.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12823"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ac6833"},{"issue":"3","key":"e_1_2_11_20_1","article-title":"Pediatric primary kidney transplant recipients outcomes by immunosuppression induction received in the united states [abstract]","volume":"20","author":"Riad SM","year":"2020","journal-title":"Am J Transplant"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000092950.54184.67"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.8495"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13265"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.03.021"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12034"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12451"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13925","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.13925","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T12:14:14Z","timestamp":1693311254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,17]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/petr.13925"],"URL":"https:\/\/doi.org\/10.1111\/petr.13925","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,17]]},"assertion":[{"value":"2020-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13925"}}