{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:16:45Z","timestamp":1789802205775,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Systemic medications categorized as diphenylhydantoin, calcineurin inhibitor and calcium channel blocker may have effects on the oral cavity by modifying the inflammatory and immune response and causing undesired tissue proliferative reactions. Calcineurin inhibitors are medications commonly used for long periods in patients undergoing allogeneic hematopoietic stem cell transplant (HSCT) and solid organ transplantation. Medication\u2010related fibrovascular hyperplasia (MRFH) is an extra gingival hyperplastic nodular growth associated with medications use. This study reports five cases of pediatric patients (6 to 12\u2010years\u2010old) diagnosed with Fanconi anemia (FA) after HSCT who presented similar oral mucosal lesions associated with the use of cyclosporine, phenobarbital and amlodipine. After excision of the lesions, histopathological analysis described them as pyogenic granuloma (PG). As the aetiology of the lesions manifested by the patients was associated with the use of medications, the final diagnosis was MRFH. Despite the clinical and histopathological similarity between PG and MRFH, it is fundamental to know the aetiological agent for achieving definitive diagnosis and correct management. Considering the etiologic agent (medication) and histopathological findings, it is suggested that the most appropriate term for this manifestation should be \u201cmedication\u2010related fibrovascular hyperplasia\u201d. The correct nomenclature related to extra gingival hyperplastic lesions identified in patients on medications with potential to induce hyperplastic reactions should be adopted to facilitate scientific communication and improve the treatment.<\/jats:p>","DOI":"10.1111\/petr.13947","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T19:30:44Z","timestamp":1608665444000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A case series of medication\u2010related fibrovascular hyperplasia following hematopoietic stem cell transplantation for Fanconi anemia"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4385-3348","authenticated-orcid":false,"given":"B\u00e1rbara Soldatelli","family":"Ballardin","sequence":"first","affiliation":[{"name":"Multiprofessional Residency Program in Oncology and Hematology, Clinic Hospital Complex Federal University of Parana Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8603-2614","authenticated-orcid":false,"given":"Rafael Zancan","family":"Mobile","sequence":"additional","affiliation":[{"name":"Post\u2010Graduate Program in Dentistry, Department of Stomatology Federal University of Parana Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0108-6593","authenticated-orcid":false,"given":"F\u00e1bio Luiz","family":"Coracin","sequence":"additional","affiliation":[{"name":"Health Department Nove de Julho University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-5146","authenticated-orcid":false,"given":"Lisandro Lima","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Service of Bone Marrow Transplant, Clinic Hospital Complex Federal University of Parana Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0343-2610","authenticated-orcid":false,"given":"Carmem Maria Sales","family":"Bonfim","sequence":"additional","affiliation":[{"name":"Service of Bone Marrow Transplant, Clinic Hospital Complex Federal University of Parana Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5204-0782","authenticated-orcid":false,"given":"Juliana Lucena","family":"Schussel","sequence":"additional","affiliation":[{"name":"Multiprofessional Residency Program in Oncology and Hematology, Clinic Hospital Complex Federal University of Parana Curitiba Brazil"},{"name":"Post\u2010Graduate Program in Dentistry, Department of Stomatology Federal University of Parana Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8049-7544","authenticated-orcid":false,"given":"Cassius","family":"Carvalho Torres\u2010Pereira","sequence":"additional","affiliation":[{"name":"Multiprofessional Residency Program in Oncology and Hematology, Clinic Hospital Complex Federal University of Parana Curitiba Brazil"},{"name":"Post\u2010Graduate Program in Dentistry, Department of Stomatology Federal University of Parana Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.09.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00557.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(94)90173-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000593"},{"key":"e_1_2_7_6_1","first-page":"1127","article-title":"Non\u2010gingival soft tissue growths after allogeneic marrow transplantation","volume":"17","author":"Woo 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literature","volume":"57","author":"Balasubramaniam R","year":"2009","journal-title":"Gen Dent"}],"container-title":["Pediatric 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