{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:09:34Z","timestamp":1785244174922,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>No consensus exists on the optimal timing for native nephrectomy in pediatric kidney transplant recipients. Data comparing outcomes between recipients undergoing pretransplant nephrectomy (staged nephrectomy with subsequent transplant) and those undergoing nephrectomy simultaneously with the transplant are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We studied 32 pediatric kidney transplant recipients who underwent native nephrectomy at a single center from 01\/01\/2011 to 12\/31\/2016. We divided recipients into two groups based on the nephrectomy timing (simultaneous nephrectomy\/transplant and staged nephrectomy). We used Wilcoxon rank\u2010sum test, Fisher's exact test, and Kaplan\u2010Meier methods to compare outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 32 recipients, 20 underwent simultaneous and 12 underwent staged nephrectomy. Simultaneous recipients were younger (median (years): 2.0 vs 7.0; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.049). Staged recipients were more likely to have proteinuria\/hypoalbuminemia, whereas simultaneous recipients were more likely to have hydronephrosis\/vesicoureteral reflux\/urinary infections as nephrectomy indications (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.06). Median prenephrectomy albumin for patients with nephrotic syndrome was significantly lower in staged recipients (median g\/dL: 1.9 vs 3.8; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). Total number of hospital days (including both procedures) was higher for staged recipients compared with simultaneous (one procedure) recipients (median (days): 17.0 vs 11.5; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.05). We observed no difference in 5\u2010year graft survival between the groups (95.0% vs 91.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.73). Patient survival was 100% in both groups over a median follow\u2010up of 44.2\u00a0months. Surgical complications were similar between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Staged and simultaneous native nephrectomy in pediatric kidney transplant recipients are associated with comparable outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13952","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T22:40:14Z","timestamp":1608244814000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Timing of native nephrectomy and kidney transplant outcomes in children"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5824-7856","authenticated-orcid":false,"given":"Sarah J.","family":"Kizilbash","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao","family":"Huynh","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varvara","family":"Kirchner","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Urology University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8836-0881","authenticated-orcid":false,"given":"Priya S.","family":"Verghese","sequence":"additional","affiliation":[{"name":"Ann &amp; Robert H Lurie Children\u2019s Hospital Chicago IL USA"},{"name":"Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"issue":"4","key":"e_1_2_6_2_1","first-page":"55","article-title":"Section IV: long\u2010term management of the transplant recipient. IV.11 Paediatrics (specific problems)","volume":"17","author":"European Best Practice Guidelines for Renal Transplantation","year":"2002","journal-title":"Nephrol Dial. Transplant"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003136"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2115-y"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2011.12.008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11060"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000181208.06507.aa"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2007.07.035"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.10.008"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11379.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"issue":"3","key":"e_1_2_6_12_1","first-page":"S1","article-title":"KDIGO clinical practice guideline for the care of kidney transplant recipients","volume":"9","year":"2009","journal-title":"Am J Transplant"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199810150-00001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01949.x"},{"key":"e_1_2_6_15_1","first-page":"305","article-title":"Renal transplantation in children with congenital nephrotic syndrome: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS)","volume":"2","author":"Kim MS","year":"1998","journal-title":"Pediatr Transplant"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80678-0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.11.012"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.08.047"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155481"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000179109.51593.87"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.13952","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.13952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T12:14:26Z","timestamp":1693311266000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.13952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,16]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/petr.13952"],"URL":"https:\/\/doi.org\/10.1111\/petr.13952","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,16]]},"assertion":[{"value":"2020-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13952"}}