{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:50:08Z","timestamp":1773071408543,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about the prevalence of hepatic graft fibrosis in combined LSBT children. We aimed to determine the prevalence of and identify potential predictors for hepatic graft fibrosis in LSBT children and to compare them with those in LT children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively included children younger than 19\u00a0years who had received a primary LT\/LSBT between 2000 and 2018 and had a liver biopsy performed at least 6\u00a0months post\u2010transplant. A Cox proportional hazards regression model was used to determine predictors associated with significant hepatic graft fibrosis (\u2265F2) in LSBT vs LT children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010six children (47 LSBT, 54 females) were included. The median post\u2010transplant follow\u2010up (years) was 12.8 in LT vs 10.5 in LSBT patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.06). Hepatic graft fibrosis was found in 81.6% of LT vs 70.2% of LSBT children (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.19), after a median time of 2.5\u00a0years and 2.6\u00a0years, respectively. On multivariate analyses, having post\u2010transplant biliary complications was found to be associated with significant graft fibrosis in LT children, whereas AST\/ALT ratio was found to predict significant hepatic graft fibrosis in LSBT children. The use of parenteral nutrition after transplant was not associated with significant hepatic graft fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of hepatic graft fibrosis in LSBT children did not significantly differ from that in LT children, but the predictors may differ. Future studies should investigate the role of post\u2010transplant autoimmune antibodies and donor\u2010specific antibodies in the development and progression of hepatic graft fibrosis in LSBT children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.13965","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T02:18:29Z","timestamp":1609381109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Post\u2010transplant hepatic fibrosis in pediatric liver\u2010small bowel transplant recipients: A single\u2010center, retrospective, observational study"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2189-3253","authenticated-orcid":false,"given":"Hanh D.","family":"Vo","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley J.","family":"Radio","sequence":"additional","affiliation":[{"name":"Pathology and Microbiology University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emille M.","family":"Reyes\u2010Santiago","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology, and Nutrition University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teri J.","family":"Mauch","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology University of Nebraska Medical Center Omaha NE 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