{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:36:48Z","timestamp":1792420608751,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T00:00:00Z","timestamp":1616803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>CKF is an overwhelming illness, especially in children. Kidney transplantation is considered the definitive management of CKF. It has substantial benefits, including increased patient survival, improved skeletal growth, social adjustment, neuropsychological development, and better quality of life compared to chronic dialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective, clinical, observational study in 13\u00a0children \u226416\u00a0years old who underwent kidney transplantation at IALCH in KwaZulu\u2010Natal, South Africa, from May 2015 to December 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 4\u00a0years and 7\u00a0months, 13\u00a0kidney transplants were performed; 7 (53.8%) were males, and 6 (46.2%) were females. Eleven (84.6%) were Black African and 2 (15.4%) Indian children. The mean age\u00a0\u00b1\u00a0(SD) of transplantation was 10.1\u00a0\u00b1\u00a02.8\u00a0years (range 5.8\u201315.8). Eight (61.5%) children were from a rural setting. The mean\u00a0\u00b1\u00a0(SD) duration of follow\u2010up was 29.5\u00a0\u00b1\u00a015.9\u00a0months. All kidney transplants done were from live related donors; 8 (61.5%) were parents of the recipients. None were pre\u2010emptive transplants. Graft loss occurred in 2 (15.4%) children with 100% patient survival. Two (15.4%) children developed acute rejection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The commissioning of transplant services in KwaZulu\u2010Natal, South Africa, has improved access to this modality of treatment, particularly in our Black African patients. The significant limitations we experienced were a shortage of cadaveric donors and resource limitations with no dedicated transplant unit for pediatric patients together with staffing constraints. Enhancing patient and healthcare personal education will hopefully overcome cultural and religious barriers to organ donation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14016","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T12:00:45Z","timestamp":1616846445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Kidney transplantation in children in KwaZulu\u2010Natal, South Africa"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7245-0519","authenticated-orcid":false,"given":"Nisreen Seed Ahmed","family":"Sinada","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Child Health Nelson R Mandela School of Medicine College of Health Sciences University of KwaZulu\u2010Natal Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaene","family":"Naicker","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health Nelson R Mandela School of Medicine College of Health Sciences University of KwaZulu\u2010Natal Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partson","family":"Tinarwo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Nelson R. 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