{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:13:42Z","timestamp":1785233622026,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemoglobin Bart's hydrops fetalis syndrome (BHFS) was once considered a fatal condition universally. Medical advances over the past three decades have resulted in increasing numbers of BHFS survivors. This retrospective review summarized local territory\u2010wide experience and outcomes of BHFS patients who received allogeneic hematopoietic stem cell transplantation (HSCT) in Hong Kong.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All BHFS patients who underwent allogeneic HSCT in Hong Kong, either in one of the two former pediatric transplant centers (Queen Mary Hospital and Prince of Wales Hospital) on or before 2019 or in the single territory\u2010wide pediatric transplant center (Hong Kong Children's Hospital) since 2019, from January 1, 1996, till December 31, 2020, were included. Basic demographic data, perinatal history, transplant details, long\u2010term outcomes, and morbidities were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total five allogeneic HSCT were performed in two males and three females at a median age of 22\u00a0months, which include one 8\/8 matched\u2010sibling bone marrow transplant, one 5\/6 matched\u2010sibling cord blood transplant with HLA\u2010DR antigenic mismatch, two 12\/12 matched\u2010unrelated peripheral blood stem cell transplant (PBSCT), and one haploidentical PBSCT with TCR\u03b1\u03b2\/CD45RA depletion from maternal donor. Neutrophil and platelet engrafted (&gt;20\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L) at a median of 15 and 22\u00a0days, respectively. All achieved near full donor chimerism at 1\u00a0month. All patients survived and remained transfusion\u2010independent without significant morbidities with median follow\u2010up duration of 10\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To conclude, local data demonstrated favorable outcome of allogeneic HSCT for BHFS patients, but sample number is small. Non\u2010directive approach in counseling and international collaboration is recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14037","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T14:20:27Z","timestamp":1621347627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Outcomes of allogeneic transplantation for hemoglobin Bart\u2019s hydrops fetalis syndrome in Hong Kong"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4178-2777","authenticated-orcid":false,"given":"Wilson Y. K.","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Hong Kong Children\u2019s Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela P. W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Hong Kong Children\u2019s Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Hong Kong Children\u2019s Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godfrey C. F.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Hong Kong Children\u2019s Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Hong Kong Children\u2019s Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Y.","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Hong Kong Children\u2019s Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel K. L.","family":"Cheuk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Hong Kong Children\u2019s Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5213.1649"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V20.5.581.581"},{"key":"e_1_2_10_4_1","first-page":"79","article-title":"Further studies in Bart\u2019s hydrops foetalis in Singapore","volume":"12","author":"Boon WH","year":"1970","journal-title":"J Singapore Paediatr Soc"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1985.tb01447.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-697110"},{"issue":"2","key":"e_1_2_10_7_1","first-page":"107","article-title":"Outcomes and morbidities 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