{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:19:07Z","timestamp":1789100347600,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Living donor liver transplantation is a treatment option for unresectable hepatic tumors in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 45 living donor transplantations performed between 1993 and 2018 for liver malignacies, which included hepatoblastoma (<jats:italic>n\u00a0=<\/jats:italic>\u00a033), hepatocellular carcinoma (<jats:italic>n\u00a0=<\/jats:italic>\u00a010), hepatic angiosarcoma (<jats:italic>n\u00a0=<\/jats:italic>\u00a01), and rhabdomyosarcoma (<jats:italic>n\u00a0=<\/jats:italic>\u00a01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No mortality or major morbidities were encountered in any donor, and the complication rate was 9%.\u00a0In the hepatoblastoma group, 5\u2010year overall and event\u2010free survival rate in recipients was 87.4% and 75.8%, respectively, and\u00a0mortality was significantly higher in patients after rescue transplantation (<jats:italic>p\u00a0=<\/jats:italic>\u00a0.001).\u00a0Inferior vena cava replacement in these recipients appeared to be associated with reduced mortality (<jats:italic>p\u00a0=<\/jats:italic>\u00a0.034),\u00a0but this was not confirmed when rescue patients were excluded (<jats:italic>p\u00a0=<\/jats:italic>\u00a0.629).\u00a0In hepatocellular carcinoma group, both 5\u2010year overall and event\u2010free survival rates were 75.4% each, and\u00a0invasion of hepatic veins was significantly associated with increased risk of recurrence and death (<jats:italic>p\u00a0=<\/jats:italic>\u00a0.028).\u00a0The patient with rhabdomyosarcoma died from EBV\u2010induced lymphoma 2\u00a0months after transplantation. The patient with angiosarcoma was in complete remission at the last follow\u2010up.\u00a0Overall, 5\u2010year graft survival rate was 81.3%,\u00a0and one patient underwent re\u2010transplantation due to chronic rejection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pediatric oncological liver transplantation has become a key player in the management of malignancies with cancer cure in 84% of patients in this series. Living donor liver transplantation for pediatric recipients with unresectable tumors might be a beneficial surgical option, which is technically safe for donors and recipients, thus, allowing timely planning according to chemotherapy protocols.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14047","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T21:59:20Z","timestamp":1622671160000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Living donor liver transplantation for hepatic malignancies in children"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3422-9482","authenticated-orcid":false,"given":"Aurore","family":"Pire","sequence":"first","affiliation":[{"name":"Pediatric and Transplantation Surgery Cliniques Universitaires Saint\u2010Luc Brussels 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