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This condition is associated with autoimmune hepatitis in less than 20% of cases, and there have only been a few reports of children with the condition who developed ALF. We present a unique case of an infant with APS\u20101 who developed ALF and subsequently required liver transplantation.<\/jats:p>","DOI":"10.1111\/petr.14048","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T17:36:42Z","timestamp":1622655402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rare genetic mutation triggering acute liver failure in a toddler requiring a liver transplant"],"prefix":"10.1111","volume":"25","author":[{"given":"Charles B.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology, and Nutrition Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nila","family":"Mistry Ambani","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology, and Nutrition Cleveland Clinic Cleveland OH 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