{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:43:19Z","timestamp":1753879399851,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>25\u2010hydroxy VD insufficiency is known in children undergoing LT but the serial post\u2010transplant VD course and supplementation modalities in the peri\u2010transplant period are lacking. We aimed to determine the pre\u2010VD status and the post\u2010transplant VD status course following VD supplementation and to elucidate its relationship with post\u2010transplant outcome parameters such as infection and survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pre\u2010 and post\u2010VD levels were monitored in parallel with interventions to adjust VD levels in LT patients. VD status was categorized as circulating levels &lt;30\u201321\u00a0ng\/ml (insufficiency), 20\u201310\u00a0ng\/ml (deficiency), and &lt;10\u00a0ng\/ml (severe deficiency). Patients received stoss (300000IU) VD3 within the pretransplant period if serum levels were &lt;20\u00a0ng\/ml.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>135 transplanted children were included. The age at LT was 22\u00a0months (IQR: 8\u201360). The pretransplant median VD level was 14\u00a0ng\/ml. Despite stoss dose, post\u2010transplant median VD level was 1.8\u00a0ng\/ml (day one), 4\u00a0ng\/ml (week one), 19\u00a0ng\/ml (month one), 33\u00a0ng\/ml (month three), 38\u00a0ng\/ml (months 6\u201312), and 40\u00a0ng\/ml (month 24). After 6\u00a0months, VD status reached &gt;30\u00a0ng\/ml in 98% of patients. Only at pre\u2010LT, higher infection rate (18.7%) in the severe VD deficiency group was observed compared to the VD deficiency group (2.9%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04). Survival was not affected by serum VD levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>VD levels fell substantially after LT but are rectifiable by stoss dose, which was well tolerated. Only the infection rate was associated with the VD status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14049","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T17:51:25Z","timestamp":1622656285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Course of vitamin D levels before and after liver transplantation in pediatric patients"],"prefix":"10.1111","volume":"25","author":[{"given":"Muhammed","family":"Yuksel","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology\u2010Hepatology Ko\u00e7 University  Istanbul Turkey"},{"name":"Liver Transplantation Center Ko\u00e7 University  Istanbul Turkey"},{"name":"Liver Immunology Lab Ko\u00e7 University Research Center for Translational Medicine (KUTTAM)  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bari\u015f","family":"Demir","sequence":"additional","affiliation":[{"name":"Pediatric 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