{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:42:29Z","timestamp":1753879349843,"version":"3.41.2"},"reference-count":2,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Immunoadsorption (IA) plasmapheresis is standard modality for pretransplant desensitization in ABO\u2010incompatible solid organ transplants though technically challenging when considered for an infant or a child less than 10\u00a0kg due to non\u2010availability of pediatric immunoadsorption (IA) columns. The major challenge is to maintain hemodynamic stability considering the large extracorporeal circuit volume meant for adults. To our best knowledge after extensive search in acclaimed global medical journals, this is the first successful attempt in an underweight (6\u00a0kg) infant of less than 1 year of age using adult size IA Column thus making it a reality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case characteristics<\/jats:title><jats:p>We report an 8\u2010month\u2010old male infant (A positive) of 6\u00a0kg with decompensated liver disease secondary to extrahepatic biliary atresia requiring urgent live donor liver transplantation with AB positive donor with significantly elevated pretransplant anti\u2010B IgG\/ IgM antibody titers &gt;1:1024. Baby underwent multiple sessions of anti\u2010B immunoadsorption plasmapheresis to lower anti\u2010B IgM \/ IgG titers using available adult anti\u2010B immunoadsorption column. Postprocedure, the antibody titers reduced to 1:8 (anti\u2010IgG) 1:16 (anti\u2010IgM) followed by successful ABO\u2010incompatible live donor liver transplant (LDLT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome<\/jats:title><jats:p>Anti\u2010B titers remained in normal range in the immediate and post\u2010transplant period with satisfactory liver functions and no rejection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Immunoadsorption plasmapheresis for ABO\u2010incompatible solid organ transplantation in infants gives desirable results and can be offered to small sized infants using currently available adult sized IA columns when conducted with adequate technical expertise.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14064","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T15:45:41Z","timestamp":1622475941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Feasibility of Immunoadsorption plasmapheresis in an infant for ABO\u2010incompatible solid organ transplant\u2014A reality"],"prefix":"10.1111","volume":"25","author":[{"given":"Saumil","family":"Gaur","sequence":"first","affiliation":[{"name":"Division of Paediatric Nephrology Rainbow Children Hospital Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Partha Pratim","family":"Paul","sequence":"additional","affiliation":[{"name":"Division of Paediatric Nephrology Rainbow Children Hospital Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mounika","family":"Motamarri","sequence":"additional","affiliation":[{"name":"Division of Paediatric Nephrology Rainbow Children Hospital Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaik Raham","family":"Tulla","sequence":"additional","affiliation":[{"name":"Division of Paediatric Nephrology Rainbow Children Hospital Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2011.01480.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13138"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14064","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.14064","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T23:40:11Z","timestamp":1693006811000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.14064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,31]]},"references-count":2,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/petr.14064"],"URL":"https:\/\/doi.org\/10.1111\/petr.14064","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2021,5,31]]},"assertion":[{"value":"2021-01-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14064"}}