{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:32:27Z","timestamp":1792171947493,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T00:00:00Z","timestamp":1626566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008868","name":"International Society for Heart and Lung Transplantation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>New drugs may further decrease the need for lung transplant (LTx) in pediatric patients with cystic fibrosis (CF), but few studies highlight pediatric non\u2010CF LTx characteristics and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The ISHLT registry was used to report morbidity, graft failure, and survival for primary pediatric (&lt;18\u00a0years) LTx performed 1990\u20132017. Recipient\/donor characteristics and long\u2010term outcomes were analyzed for CF and non\u2010CF recipients. Survival was assessed using Kaplan\u2013Meier curves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2232 primary LTx, (43% in males), 918 (41%) were performed for non\u2010CF indications; most commonly pulmonary hypertension (43%). Non\u2010CF patients were younger (median age 11 vs. 15, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.001), and more frequently on inotropes and\/or extracorporeal membrane oxygenation (15% vs. 2.4%, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.001) at transplant, compared to CF recipients. In\u2010hospital major complications more commonly affected CF LTx recipients (57% vs. 48%, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.003), but 30\u2010day mortality was higher in the non\u2010CF group (9% non\u2010CF vs. 5% CF, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.001). One\u2010, five\u2010, and ten\u2010year mortality was 18%, 50%, and 65% for CF recipients, respectively, and 21%, 45%, and 58% for non\u2010CF recipients (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.01 at 10\u00a0years). Five\u2010year survival was significantly better for non\u2010CF females versus CF females (56% vs. 48%, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.013), but was similar between groups for males (55% vs. 54%, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.305). While age was a late outcomes risk factor, pulmonary hypertension and later transplants eras were protective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early mortality is higher and late mortality is lower in non\u2010CF LTx. Current non\u2010CF LTx outcomes leave room for improvement. Further study is needed to evaluate the effects of center volume and pediatric\u2010specific experience on outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14086","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T15:03:18Z","timestamp":1626620598000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A shifting landscape: Practice patterns and outcomes of cystic fibrosis and non\u2010cystic fibrosis pediatric lung transplantation"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9656-1125","authenticated-orcid":false,"given":"Jennifer S.","family":"Nelson","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Services Nemours Children\u2019s Hospital Orlando FL USA"},{"name":"University of Central Florida College of Medicine Orlando FL 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