{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:45:50Z","timestamp":1766450750357,"version":"3.41.2"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T00:00:00Z","timestamp":1627257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrence of SRNS is a major challenge in KT. Several clinical factors, including initial steroid sensitivity, have been associated with increased post\u2010transplant SRNS recurrence risk. However, conflicting data have been reported, possibly due to the heterogeneous pathophysiology of SRNS and the lack of genetic testing of SRNS patients. Furthermore, the response to immunosuppressive therapies has not been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy patients aged 1\u201315\u00a0years at SRNS onset who underwent KT between 2002 and 2018 were enrolled. Patients with secondary, familial, syndromic, and genetic forms of SRNS and those who were not treated with steroid were excluded. This study aimed to assess the risk factors for post\u2010transplant recurrence, including treatment responses to initial steroid therapy and additional therapies with immunosuppressive agents, rituximab, plasmapheresis, and\/or LDL\u2010A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 36 kidney transplant recipients were analyzed. Twenty\u2010two (61%) patients experienced post\u2010transplant SRNS recurrence, while 14 patients did not. The proportion of patients who achieved complete or partial remission with initial steroid therapy and\/or additional therapies with immunosuppressive agents, rituximab, plasmapheresis, and\/or LDL\u2010A was significantly higher in the SRNS recurrence group (19\/22, 86%) than in the group without SRNS recurrence (6\/14, 43%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that the response to steroid treatment, other immunosuppressive agents, rituximab, plasmapheresis, and\/or LDL\u2010A may predict post\u2010transplant SRNS recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14103","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T09:19:42Z","timestamp":1627291182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Response to steroid and immunosuppressive therapies may predict post\u2010transplant recurrence of steroid\u2010resistant nephrotic syndrome"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9483-8482","authenticated-orcid":false,"given":"Kenichiro","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology Tokyo Women\u2019s Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Tokyo Women\u2019s Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichiro","family":"Kanda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Tokyo Women\u2019s Medical University  Tokyo Japan"},{"name":"Department of Pediatrics The University of Tokyo  Tokyo 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