{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:34:41Z","timestamp":1782603281112,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epstein\u2010Barr virus (EBV) is a DNA virus with oncogenic potential, especially in immunocompromised patients. EBV can promote smooth muscle proliferation, resulting in EBV\u2010associated smooth muscle tumors (EBV\u2010SMT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report a case of a 10\u2010year\u2010old child with end\u2010stage renal disease secondary to hypoplastic crossed and fused kidneys who underwent kidney transplantation. EBV serology was unknown for the donor and negative for the recipient; three months after he had a primary EBV infection. Two years after the transplantation, percutaneous nephrostomy was performed because of a drop in the estimated glomerular filtration rate and severe dilatation of the graft. Nephrography showed contrast enhancement of the pelvis of the graft kidney and proximal ureter, with a clear blockage at the level of the mid ureter and no passage towards the bladder. A 1.5\u2010cm tumor was found causing intraluminal compression of the mid ureter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete resection of the tumor and distal ureter was performed leaving a short proximal ureter. A tension\u2010free uretero\u2010ureteroanastomoses was achieved using the native ureter. There were no surgical complications. Histologic evaluation showed spindle\u2010shaped muscle cells, moderate pleomorphism, and inflammatory infiltration. Immunohistochemical staining was positive for muscle\u2010specific actin. Epstein\u2010Barr encoding region (EBER) in situ hybridization was positive, confirming the diagnosis of EBV\u2010associated SMT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EBV\u2013SMT is an exceedingly rare oncological entity that may develop in either the graft or any other organ. The clinical findings are location related. EBV seroconversion following transplantation might be a risk factor for the development of SMT in solid organ recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14109","type":"journal-article","created":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T06:53:05Z","timestamp":1628319185000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["\u201cEpstein\u2010Barr virus associated smooth muscle tumour as an unusual cause of ureteric graft obstruction in a child\u201d"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5104-3682","authenticated-orcid":false,"given":"Mar\u00eda Tatiana","family":"Szklarz","sequence":"first","affiliation":[{"name":"Pediatric Urology Department. Hospital de Pediatria Pr Dr Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9328-6746","authenticated-orcid":false,"given":"Catalina","family":"Tessi","sequence":"additional","affiliation":[{"name":"Pediatric Urology Department. Hospital de Pediatria Pr Dr Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7460-8025","authenticated-orcid":false,"given":"Javier","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Pediatric Urology Department. Hospital de Pediatria Pr Dr Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0595-1644","authenticated-orcid":false,"given":"Nicolas Ignacio","family":"Rosiere","sequence":"additional","affiliation":[{"name":"Pediatric Urology Department. Hospital de Pediatria Pr Dr Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7573-1105","authenticated-orcid":false,"given":"Felicitas","family":"Lopez Imizcoz","sequence":"additional","affiliation":[{"name":"Pediatric Urology Department. Hospital de Pediatria Pr Dr Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4975-2791","authenticated-orcid":false,"given":"Santiago","family":"Weller","sequence":"additional","affiliation":[{"name":"Pediatric Urology Department. Hospital de Pediatria Pr Dr Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica Ester","family":"Solernou","sequence":"additional","affiliation":[{"name":"Pathology Department. Hospital de Pediatria Pr Dr Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-2066","authenticated-orcid":false,"given":"Marta Lidia","family":"Monteverde","sequence":"additional","affiliation":[{"name":"Nephrology Department. Hospital de Pediatria Pr Dr Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1094-338X","authenticated-orcid":false,"given":"Juan Pablo","family":"Corbetta","sequence":"additional","affiliation":[{"name":"Pediatric Urology Department. Hospital de Pediatria Pr Dr Juan P Garrahan Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1283285"},{"key":"e_1_2_8_3_1","volume-title":"Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis.esviruses: Biology, Therapy, and Immunoprophylaxis","author":"Nancy R\u2010T","year":"2007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501053320104"},{"key":"e_1_2_8_5_1","first-page":"13465","article-title":"Epstein\u2010Barr virus\u2010associated smooth muscle tumor in a kidney transplant recipient: A case\u2010report and review of the literature","volume":"28","author":"Tardieu L","year":"2020","journal-title":"Transpl Infect Dis"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04011.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0120-RS"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12426"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13068"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.26396"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12841"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70943-3"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.14109","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:39:48Z","timestamp":1693204788000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.14109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,6]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/petr.14109"],"URL":"https:\/\/doi.org\/10.1111\/petr.14109","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,6]]},"assertion":[{"value":"2021-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14109"}}