{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:55:42Z","timestamp":1780322142863,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Impaired bone mineral density (BMD) and osteoporosis are commonly found in patients who have undergone heart transplantation (HT), which increases the risk for bone fractures which is associated with increased morbidity and mortality in adults. However, the long\u2010term evolution of BMD after HT in pediatric patients has not been thoroughly investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Bone mineral density up to 10\u00a0years after HT was investigated in 30 patients who underwent HT at an age &lt;20\u00a0years at Sk\u00e5ne University Hospital in Lund 1988\u20132016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total observed time was 235 person\u2010years. Before HT, 86% had low BMD for chronologic age in the lumbar spine. In lumbar spine, BMD was significantly lower than normal for chronological age before HT (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.034), but recovered at the 4th year (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.009). In whole body, BMD was normal at the 4th annual check\u2010up (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.030) and remained so throughout the follow\u2010up period. The median <jats:italic>T<\/jats:italic> score in the lumbar spine and femoral neck 10\u00a0years after HT did not differ between the two groups based on age at HT (&lt;20\u00a0years vs 20\u00a0years or older; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.779 in the lumbar spine and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.388 in the femoral neck).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients who undergo HT at an age of &lt;20\u00a0years have low BMD for chronological age already before HT, but BMD may recover completely within the first 4\u00a0years after HT. The results indicate no difference in BMD at 10\u00a0years after HT between pediatric and adult patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14127","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T05:31:20Z","timestamp":1630474280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bone mineral density in pediatric heart transplanted patients: A retrospective single\u2010center study at Sk\u00e5ne University Hospital in Lund 1988\u20132016"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8976-0801","authenticated-orcid":false,"given":"Eveline","family":"L\u00f6fdahl","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund Cardiology Lund University Lund Sweden"},{"name":"The Section for Heart Failure and Valvular Disease VO. Heart and Lung Medicine Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Tran\u2010Lundmark","sequence":"additional","affiliation":[{"name":"The Pediatric Heart Center Sk\u00e5ne University hospital Lund Sweden"},{"name":"Wallenberg Center for Molecular Medicine Lund University Lund Sweden"},{"name":"Department of Experimental Medical Science Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0415-6355","authenticated-orcid":false,"given":"Carl","family":"Hagg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund Cardiology Lund University Lund Sweden"},{"name":"The Section for Heart Failure and Valvular Disease VO. 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