{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T21:48:51Z","timestamp":1771019331756,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,5]],"date-time":"2021-09-05T00:00:00Z","timestamp":1630800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 CA112530"],"award-info":[{"award-number":["RO1 CA112530"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 CA113930"],"award-info":[{"award-number":["RO1 CA113930"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["1UL1\u2010RR033183"],"award-info":[{"award-number":["1UL1\u2010RR033183"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Childhood cancer survivors who received a hematopoietic cell transplantation (HCT) are at increased risk for follicle\u2010stimulating hormone (FSH) abnormalities, which may have a significant negative impact on bone health and body composition. This study's purpose was to examine FSH and body composition in HCT recipients, non\u2010HCT recipients and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included HCT recipients (<jats:italic>n<\/jats:italic>\u00a0=\u00a024), non\u2010HCT recipients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0309), and a control group of healthy siblings (<jats:italic>n<\/jats:italic>\u00a0=\u00a0211) all aged 9\u201318\u00a0years. A fasting blood sample was collected to measure FSH. All participants underwent a dual X\u2010ray absorptiometry scan to assess total and regional percent fat, lean mass (LM), fat mass (FM), bone mineral content (BMC), bone mineral density (BMD), and visceral adipose tissue (VAT) mass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FSH was significantly higher in HCT recipients compared to non\u2010HCT recipients and healthy controls. HCT recipients had significantly lower total body weight, total LM, arm and leg LM, BMC and BMD compared to non\u2010HCT recipients and healthy controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Non\u2010HCT recipients had significantly higher total, trunk, android, gynoid, arm and leg FM compared to healthy controls. Also, healthy controls had significantly lower VAT mass compared to non\u2010HCT recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study's results show that HCT recipients have significant reductions in BMD, worse body composition, and abnormal FSH levels compared to non\u2010HCT recipients and healthy controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14130","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T02:36:15Z","timestamp":1630895775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of FSH in body composition in hematopoietic cell transplant recipients"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4474-7996","authenticated-orcid":false,"given":"Erica J.","family":"Roelofs","sequence":"first","affiliation":[{"name":"School of Kinesiology University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald R.","family":"Dengel","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Biostatistical Design and Analysis Center University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Hodges","sequence":"additional","affiliation":[{"name":"Division of Biostatistics University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Steinberger","sequence":"additional","affiliation":[{"name":"University of Minnesota Medical Center Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Baker","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,5]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"D\u2019SouzaA&FrethamC.Current uses and outcomes of hematopoietic cell transplantation (HCT): CIBMRT summary slides.2019.https:\/\/www.cibmtr.org. 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