{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:57:24Z","timestamp":1792641444600,"version":"4.5.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T00:00:00Z","timestamp":1633219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mutations in the <jats:italic>ADCK4<\/jats:italic>\u00a0gene cause steroid\u2010resistant nephrotic syndrome (NS), namely <jats:italic>ADCK4<\/jats:italic>\u2010associated glomerulopathy. Reportedly, 38.5% of patients with <jats:italic>ADCK4<\/jats:italic>\u2010associated glomerulopathy had end\u2010stage renal disease (ESRD) at the time of diagnosis of <jats:italic>ADCK4<\/jats:italic>\u2010associated glomerulopathy, requiring renal replacement therapy, such as dialysis and kidney transplantation. However, long\u2010term NS recurrence risk of kidney transplantation in patients with <jats:italic>ADCK4<\/jats:italic>\u2010associated glomerulopathy is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical data and mutations in <jats:italic>ADCK4<\/jats:italic> of two siblings with steroid\u2010resistant NS were collected. The long\u2010term prognosis of the two siblings who received kidney transplantation was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We describe two siblings with <jats:italic>ADCK4<\/jats:italic>\u2010associated glomerulopathy who received deceased donor kidney transplantation and showed no clinical evidence of recurrence of NS during more than 10\u00a0years of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This suggests that long\u2010term NS recurrence risk of kidney transplantation is low in patients with <jats:italic>ADCK4<\/jats:italic>\u2010associated glomerulopathy who progress to ESRD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14143","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T02:23:55Z","timestamp":1633400635000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010term nephrotic syndrome recurrence risk of kidney transplantation in two siblings with <i>ADCK4<\/i>\u2010associated glomerulopathy"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4958-3668","authenticated-orcid":false,"given":"Si","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics Dongfang Hospital Fuzong Clinical Medical College Fujian Medical University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology and Immunology Fujian Children\u2019s Hospital Affiliated Hospital of Fujian Medical University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dongfang Hospital Fuzong Clinical Medical College Fujian Medical University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology and Immunology Fujian Children\u2019s Hospital Affiliated Hospital of Fujian Medical University Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2304-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03800609"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11440919"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3657-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69000"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3634-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014121240"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-017-0392-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3590-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200202150-00013"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000113552.59155.72"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60236-X"}],"container-title":["Pediatric 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