{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:44:17Z","timestamp":1753879457011,"version":"3.41.2"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with autoimmune inflammatory syndromes such as mixed connective tissue disease (MCTD) and systemic lupus erythematosus have previously been considered marginal candidates for orthotopic heart transplant (OHT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was completed for this case report.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We present the case of an 11\u2010year\u2010old girl with known MCTD who developed congestive heart failure refractory to medical therapy and underwent OHT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite her autoimmune condition, this patient has not experienced antibody\u2010mediated rejection post\u2010transplant and her inflammatory symptoms have greatly improved.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14144","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T05:34:53Z","timestamp":1632202493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Orthotopic heart transplant in a pediatric patient with mixed connective tissue disease"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4605-5640","authenticated-orcid":false,"given":"Chelsea","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology University of Virginia Children\u2019s Hospital Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelby","family":"White","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology University of Virginia Children\u2019s Hospital Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"L\u2019Ecuyer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology University of Virginia Children\u2019s Hospital Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"McCulloch","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology University of Virginia Children\u2019s Hospital Charlottesville Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"issue":"2","key":"e_1_2_6_2_1","first-page":"136","article-title":"Undifferentiated connective tissue disease, mixed connective tissue disease, and overlap syndromes in rheumatology","volume":"113","author":"Pepmueller PH","year":"2016","journal-title":"Mo 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S","year":"2019","journal-title":"Eur Heart J Case Rep"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v4.i3.176"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.14144","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T08:29:41Z","timestamp":1725611381000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.14144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,20]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/petr.14144"],"URL":"https:\/\/doi.org\/10.1111\/petr.14144","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2021,9,20]]},"assertion":[{"value":"2021-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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