{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:56:39Z","timestamp":1790733399116,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The most frequently reported malignancies after solid organ transplant are cutaneous, but data on the risk in pediatric populations varies across studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To perform a systematic review including reported features and outcomes of skin cancers in pediatric solid organ transplant recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>EMBASE and MEDLINE were systematically searched (Prospero CRD42020201659).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The review summarizes data from 20\u00a0studies on 337 patients, with a median age ranging from 15.0 to 19.5\u00a0years as reported in 4\u00a0studies, who developed skin malignancies after pediatric solid organ transplantation. Median ages at transplant and skin cancer diagnosis ranged from 1.5 to 17.0\u00a0years and 15.3 to 33.5\u00a0years, respectively. Squamous cell carcinoma (SCC) was most commonly reported (218 cases), followed by basal cell carcinoma (BCC) (91 cases), melanoma (18 cases), and unspecified keratinocyte carcinomas (2 cases). The median latency period between transplantation and cancer diagnosis ranged from 2.2 to 21.0\u00a0years. Overall, 4\u00a0studies reported 17 cases of metastasis in total, and recurrence was reported in one case. Six deaths were reported in one study related to SCC and melanoma metastases. The incidence rate of skin cancer after pediatric transplantation per 100 person\u2010years of follow\u2010up was 2.1 based on 5\u00a0studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The most frequent post\u2010transplant malignancy in pediatric organ transplant recipients was SCC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14146","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T10:11:02Z","timestamp":1632564662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Outcomes of skin cancers in pediatric solid organ transplant patients: A systematic review"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2252-5663","authenticated-orcid":false,"given":"Muskaan","family":"Sachdeva","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Toronto Toronto ON 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