{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:06:45Z","timestamp":1793862405628,"version":"4.6.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In the developed world, studies on transition of adolescent renal transplant patients have noted high rates of rejection, non\u2010adherence and graft loss. There is a paucity of data in developing countries and none from South Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated patient and graft outcomes during adolescence (10\u201319\u00a0years), of patients who received a renal transplant over a 20\u2010year period (1990\u20132010), at a tertiary hospital in Johannesburg. Cox proportional hazards models and Kaplan\u2010Meier curves were used to analyse graft and patient survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 213\u00a0kidney transplants were done in 162 patients during the study period, 165 transplants occurred during the adolescent period. Factors associated with graft failure on multivariate analysis included non\u2010white race, transplant during the adolescent period ([aHR] 3.94; 95% [CI], 2.25\u20136.91), non\u2010compliance with follow\u2010up (aHR 3.89; 95% CI, 1.76\u20138.60) and receipt of a DD graft (aHR 2.10; 95% CI, 1.27\u20133.48). Patient survival rates at 1\u2010, 3\u2010, 5\u2010 and 10\u2010years were 98.8%, 97.6%, 95.1% and 93.9% respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High rates of graft rejection and loss occurred in South African renal transplant recipients in the adolescent period, especially in those retained in paediatric care. Establishment of transition clinics may improve the graft outcomes of this vulnerable group and warrant further research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14148","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T22:34:14Z","timestamp":1632782054000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Factors associated with graft survival in South African adolescent renal transplant patients at CMJAH over a 20\u2010year period (GRAFT\u2010SAT Study)"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3112-0836","authenticated-orcid":false,"given":"Priya Darshani","family":"Chhiba","sequence":"first","affiliation":[{"name":"Department of Paediatrics Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Chris Hani Baragwanath Academic Hospital and Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecil","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Nelson Mandela Children\u2019s Hospital and Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Do Vale","sequence":"additional","affiliation":[{"name":"Mediclinic Morningside Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","first-page":"1","article-title":"KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"2013","author":"Group KDIGOKCW","year":"2012","journal-title":"Kidney Inter"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.4.e382"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.21804\/20-1-2583"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1939-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2015.8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-2000-z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-25"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0044-2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0871-5"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00356.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412303"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1073-4449(96)80041-0"},{"key":"e_1_2_10_14_1","unstructured":"Organ Procurement and Transplant Network; Data. 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