{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:33:29Z","timestamp":1753878809574,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to describe the incidence, risk factors, and clinical outcomes of pericardial effusions within 6\u00a0months after pediatric heart transplantation (HT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center retrospective cohort study was performed on all pediatric HT recipients from 2004 to 2018. Logistic regression was used to identify factors associated with pericardial effusions post\u2010HT, and survival was compared using log\u2010rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 97 HTs were performed in 93 patients. Fifty patients (52%) had a \u2265small pericardial effusion within 6\u00a0months, 16 of which were, or became, \u2265moderate in size. Pericardial drain was placed in 8 patients. In univariate analysis, larger recipient body surface area (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.01) and non\u2010congenital heart disease (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.002) were associated with pericardial effusion development. Donor\/recipient size ratios, post\u2010HT hemodynamics, and rejection did not correlate with pericardial effusion development. In multivariable analysis, non\u2010congenital heart disease (adjusted odds ratio 3.3, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.01) remained independently associated with development of pericardial effusion. There were no significant differences in post\u2010HT survival between patients with and without \u2265small (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.68) or \u2265moderate pericardial effusions (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.40).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pericardial effusions are common after pediatric HT. Patients with cardiomyopathy, or non\u2010congenital heart disease, were at higher risk for post\u2010HT pericardial effusions. Pericardial effusions increased morbidity but had no effect on mortality in our cohort. The risk factors identified may be used for anticipatory guidance in pediatric HT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14153","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T07:09:05Z","timestamp":1632899345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictors and clinical significance of pericardial effusions after pediatric heart transplantation"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7329-9806","authenticated-orcid":false,"given":"Daniel","family":"McAree","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology University of Michigan Congenital Heart Center C.S. Mott Children\u2019s Hospital Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunkyung","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology University of Michigan Congenital Heart Center C.S. Mott Children\u2019s Hospital Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt R.","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology University of Michigan Congenital Heart Center C.S. Mott Children\u2019s Hospital Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray","family":"Lowery","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology University of Michigan Congenital Heart Center C.S. Mott Children\u2019s Hospital Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4874-854X","authenticated-orcid":false,"given":"Amanda D.","family":"McCormick","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology University of Michigan Congenital Heart Center C.S. Mott Children\u2019s Hospital Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thor","family":"Thorsson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology University of Michigan Congenital Heart Center C.S. Mott Children\u2019s Hospital Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7763-7518","authenticated-orcid":false,"given":"David M.","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology University of Michigan Congenital Heart Center C.S. Mott Children\u2019s Hospital Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90666-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.124387"},{"key":"e_1_2_8_4_1","first-page":"128","article-title":"Clinical significance of pericardial effusion after heart transplantation","volume":"7","author":"Vandenberg BF","year":"1988","journal-title":"J Heart Transplant"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.11.014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80085-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2003.11.400"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.3.603"},{"key":"e_1_2_8_9_1","first-page":"714","article-title":"Pericardial effusion unrelated to surgery is a predictor of mortality in heart transplant patients","volume":"25","author":"Stampfli SF","year":"2018","journal-title":"Cardiol J"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-016-1540-2"},{"key":"e_1_2_8_11_1","first-page":"170","article-title":"Postpericardiotomy syndrome in pediatric heart transplant recipients. Immunologic characteristics","volume":"22","author":"Cabalka AK","year":"1995","journal-title":"Tex Heart Inst J"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13275"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.03.019"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.08.011"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.12.010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-018-2031-4"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13290"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13639"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.14153","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T08:28:40Z","timestamp":1725611320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.14153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,28]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/petr.14153"],"URL":"https:\/\/doi.org\/10.1111\/petr.14153","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2021,9,28]]},"assertion":[{"value":"2021-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14153"}}