{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:43:28Z","timestamp":1753879408162,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["1KL2TR003097"],"award-info":[{"award-number":["1KL2TR003097"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006082","name":"Society for Surgery of the Alimentary Tract","doi-asserted-by":"publisher","award":["1KL2TR003097"],"award-info":[{"award-number":["1KL2TR003097"]}],"id":[{"id":"10.13039\/100006082","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["5R01DK113980","T35DK116670"],"award-info":[{"award-number":["5R01DK113980","T35DK116670"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The pediatric obesity epidemic is associated with early development of hepatic macrosteatosis, a hallmark of non\u2010alcoholic fatty LI disease, which is thought to be more rapidly progressive in children than adults. Macrosteatosis in adult allografts is associated with allograft loss, but this has not been examined in pediatric donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied all pediatric potential whole LI donors (2005\u20132018) who had a LI biopsy in the SRTR (<jats:italic>n<\/jats:italic>\u00a0=\u00a0862) and whose LI was transplanted (<jats:italic>n<\/jats:italic>\u00a0=\u00a0862). Macrosteatosis was abstracted from biopsy reports and compared to values in the SRTR standard analytic file. Recipients of macrosteatotic pediatric allografts were matched 1:1 to recipients of non\u2010macrosteatotic pediatric allografts by propensity score matching on donor\/recipient variables. All\u2010cause allograft loss was estimated via Kaplan\u2013Meier analysis and Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2005 to 2018, the proportion of pediatric donors (age \u22652\u00a0years) with obesity increased (14.8% to 21.7%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), as did the proportion of pediatric deceased whole LI\u2010only donor allografts with macrosteatosis (<jats:italic>n<\/jats:italic>\u00a0=\u00a010\u00a0648; 1.8% to 3.9%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). The median degree of macrosteatosis among macrosteatotic donors was 10% (IQR 5\u201330). There were no significant differences in all\u2010cause allograft loss between recipients of pediatric LI allografts with and without macrosteatosis at 90\u00a0days (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.11) or 1\u00a0year (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.14) post\u2010transplant in Kaplan\u2013Meier analysis or a Cox proportional hazards model (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Obese pediatric LI donors have increased over time and were more likely to have hepatic macrosteatosis; however, pediatric macrosteatosis did not appear to adversely affect recipient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14155","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T08:35:12Z","timestamp":1632990912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hepatic macrosteatosis in the US pediatric deceased liver donor population"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8910-2948","authenticated-orcid":false,"given":"Joshua W.","family":"Purvis","sequence":"first","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-7135","authenticated-orcid":false,"given":"Babak J.","family":"Orandi","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepti","family":"Dhall","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandler","family":"McLeod","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz Helena","family":"Gutierrez Sanchez","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition Department of Pediatrics University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meagan","family":"Gray","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayla","family":"Frey","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saulat S.","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norah A.","family":"Terrault","sequence":"additional","affiliation":[{"name":"Division of Gastrointestinal and Liver Diseases Department of Medicine University of Southern California Keck School of Medicine Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2301-5796","authenticated-orcid":false,"given":"Cora E.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayme E.","family":"Locke","sequence":"additional","affiliation":[{"name":"Division of Transplantation Department of Surgery University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"America\u2019s Move to Raise A Healthier Generation of Kids | Let\u2019s Move!Accessed September 27 2020.https:\/\/letsmove.obamawhitehouse.archives.gov\/about"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007\u20102329C"},{"key":"e_1_2_9_4_1","unstructured":"School Health Guidelines|Healthy Schools|CDC. 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