{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:21:09Z","timestamp":1793809269113,"version":"4.6.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T00:00:00Z","timestamp":1634947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Split liver transplantation (SLT) is a strategy to address organ shortage, but is a technically more demanding procedure than whole graft liver transplantation (LT). We aimed to determine the outcomes following SLT in adult recipients as well as to highlight the impact that having a pediatric LT program has on SLT implementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All SLTs conducted at a single\u2010center from 2010 to 2019 were identified. Patient data was obtained through retrospective review of the electronic medical record. Kaplan\u2013Meier analysis assessed primary outcomes of 1\u2010,3\u2010, and 5\u2010year graft and patient survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 37 SLTs performed at our institution from 2010 to 2019. Twenty\u2010four donated livers resulted in 21 extended right lobes and 16 left lateral segments for adults and pediatrics recipients, respectively. Eighty\u2010one percent (30\/37) of the SLTs were performed after introduction of the combined pediatric program in 2016. 13\/24 donor livers were split with both grafts allocated and used at our institution and 92% occurred after introduction of the pediatric program. Graft survival rates at 1\u2010, 3\u2010, and 5\u2010years were 94% in adult recipients and 100% for all time periods in pediatric recipients. Actuarial post\u2010transplant patient survival was 100% at 1\u2010, 3\u2010, and 5\u2010years in both.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The introduction of a pediatric liver transplantation program resulted in more than a fourfold increase in the number of SLTs performed at our center. Increase in allocation and use of both grafts at our institution was also seen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14159","type":"journal-article","created":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T15:55:33Z","timestamp":1635004533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increased use of split liver grafts in adult recipients following implementation of a pediatric liver transplant program"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-6665","authenticated-orcid":false,"given":"Paola Andrea","family":"Vargas","sequence":"first","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery University of Virginia Health System  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-9879","authenticated-orcid":false,"given":"Jonathan Michael","family":"Cullen","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery University of Virginia Health System  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Dalzell","sequence":"additional","affiliation":[{"name":"School of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"DiPaola","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology Department of Pediatrics University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery University of Virginia Health System  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0899-7234","authenticated-orcid":false,"given":"Kyle A.","family":"Soltys","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery University of Virginia Health System  Charlottesville Virginia USA"},{"name":"Hillman Center for Pediatric Transplantation UPMC Children\u2019s Hospital of Pittsburgh and Department of Surgery University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2624-8632","authenticated-orcid":false,"given":"George Vincent","family":"Mazariegos","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery University of Virginia Health System  Charlottesville Virginia USA"},{"name":"Hillman Center for Pediatric Transplantation UPMC Children\u2019s Hospital of Pittsburgh and Department of Surgery University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Oberholzer","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery University of Virginia Health System  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6623-5561","authenticated-orcid":false,"given":"Nicolas","family":"Goldaracena","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery University of Virginia Health System  Charlottesville Virginia 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