{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:47:08Z","timestamp":1758631628416,"version":"3.41.2"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The SARS\u2010CoV\u20102 pandemic brought challenges to all areas of medicine. In pediatric bone marrow transplant (BMT), one of the biggest challenges was determining how and when to transplant patients infected with SARS\u2010CoV\u20102 while mitigating the risks of COVID\u2010related complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our joint adult and pediatric BMT program developed protocols for performing BMT during the pandemic, including guidelines for screening and isolation. For patients who tested positive for SARS\u2010CoV\u20102, the general recommendation was to delay BMT for at least 14\u00a0days from the start of infection and until symptoms improved and the patient twice tested negative by polymerase chain reaction (PCR). However, delaying BMT in patients with malignancy increases the risk of relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We opted to transplant two SARS\u2010CoV\u20102 persistently PCR positive patients with leukemia at high risk of relapse. One patient passed away early post\u2010BMT of a transplant\u2010related complication. The other patient is currently in remission and doing well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These cases demonstrate that when the risk associated with delaying BMT is high, it may be reasonable to proceed to transplant in pediatric leukemia patients infected with SARS\u2010CoV\u20102.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14179","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T06:27:40Z","timestamp":1635402460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hematopoietic stem cell transplant in two pediatric patients testing positive for SARS\u2010CoV\u20102: A case report"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6226-965X","authenticated-orcid":false,"given":"Jennifer","family":"Krajewski","sequence":"first","affiliation":[{"name":"Pediatric Blood and Marrow Transplantation Hackensack University Medical Center Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Pediatric Hematology &amp; Oncology Hackensack University Medical Center Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhi","family":"Motiani","sequence":"additional","affiliation":[{"name":"Pediatrics Hackensack University Medical Center Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aryeh","family":"Baer","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases Hackensack University Medical Center Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burton","family":"Appel","sequence":"additional","affiliation":[{"name":"Pediatric Hematology &amp; Oncology Hackensack University Medical Center Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Zakrzewski","sequence":"additional","affiliation":[{"name":"Pediatric Blood and Marrow Transplantation Hackensack University Medical Center Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Hankewycz","sequence":"additional","affiliation":[{"name":"Pediatric Blood and Marrow Transplantation Hackensack University Medical Center Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Durning","sequence":"additional","affiliation":[{"name":"Pediatric Blood and Marrow Transplantation Hackensack University Medical Center Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"Gillio","sequence":"additional","affiliation":[{"name":"Pediatric Blood and Marrow Transplantation Hackensack University Medical Center Hackensack New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2020.07.027"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-0919-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30429-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2021.01.022"},{"volume-title":"Multisystem Inflammatory Syndrome in Children (MIS\u2010C) Interim Guidance","year":"2021","author":"Services.aap.org","key":"e_1_2_8_6_1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6932e2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41616"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0094-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.246"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.10008"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.14179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T09:23:20Z","timestamp":1725441800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.14179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,27]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/petr.14179"],"URL":"https:\/\/doi.org\/10.1111\/petr.14179","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2021,10,27]]},"assertion":[{"value":"2021-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14179"}}