{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:23:23Z","timestamp":1767993803319,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients who have a prolonged stay in the intensive care unit (ICU) are often excluded for organ donation because of supposed deleterious effects of a lengthy ICU stay. We aimed to determine the effects of a prolonged donor stay in the ICU on the outcome of liver transplantation (LT) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of 89 pediatric LT patients, age 0\u201318\u00a0years, period 2003\u20132018, including patients having undergone whole organ or in situ split LT. The patients were divided into two groups according to the donor length of stay in the ICU. A prolonged stay was defined as &gt;5\u00a0days. Recipient, graft, and donor characteristics were compared; outcome parameters included recipient and graft survival rates and postoperative complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Group <jats:italic>short<\/jats:italic> (donor ICU stay &lt;5\u00a0days) included 75 patients, group <jats:italic>long<\/jats:italic> (donor ICU stay &gt;5\u00a0days) 14 patients. Baseline characteristics between recipients did not differ. Donors in group <jats:italic>long<\/jats:italic> had significantly more infectious complications and a higher gamma glutamyl transferase (gGT) the day of organ recovery. Incidence of biliary complications post\u2010LT was significantly higher in group <jats:italic>long<\/jats:italic> (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.029). Patient and graft survival rates did not differ significantly between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Donors with a prolonged stay in the ICU should still be considered for liver donation if they fulfill most other selection criteria. Recipients from donors having stayed in ICU &gt;5\u00a0days may be at increased risk of biliary complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14186","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T10:25:00Z","timestamp":1636107900000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of length of donor ICU stay on outcome of patients after pediatric liver transplantation with whole and in situ split liver grafts"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9948-0208","authenticated-orcid":false,"given":"Aline","family":"Misar","sequence":"first","affiliation":[{"name":"Pediatric Surgery Unit Department of Pediatrics, Gynecology, and Obstetrics Swiss Pediatric Liver Center University Center of Pediatric Surgery of Western Switzerland University of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie A.","family":"McLin","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Hepatology and Nutrition Unit Department of Pediatrics, Gynecology, and Obstetrics Swiss Pediatric Liver Center University of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3813-8991","authenticated-orcid":false,"given":"Ana M.","family":"Calinescu","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit Department of Pediatrics, Gynecology, and Obstetrics Swiss Pediatric Liver Center University Center of Pediatric Surgery of Western Switzerland University of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara E.","family":"Wildhaber","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Unit Department of Pediatrics, Gynecology, and Obstetrics Swiss Pediatric Liver Center University Center of Pediatric Surgery of Western Switzerland University of Geneva Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2003.50050"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24646"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9852017"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000178184.97813.52"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.1.192"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200002000-00016"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20106576.2005.00702.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq025"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181f3dec5"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoaxjnl\u20102019\u2010213779"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373\u2010200002000\u201000006"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl\u20102018\u2010213020"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.02.010"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/It.20811"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2019.03.054"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.08.053"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2013.832486"},{"key":"e_1_2_10_19_1","unstructured":"CotlerSJ BrownRS RobsonKM(ed.).Liver transplantation: Donor selection.UpToDate.2017. Accessed 8th July 2018.https:\/\/www.uptodate.com\/contents\/liver\u2010transplantation\u2010donor\u2010selection?search=liver%20transplantation&source=search_result&selectedTitle=6~150&usage_type=default&display_rank=6"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890\u2010199202010\u201000022"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200410"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890\u2010199304000\u201000024"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000158877.74629.AA"},{"issue":"3","key":"e_1_2_10_24_1","first-page":"105","article-title":"Blood product transfusion in liver transplantation and its impact on short\u2010term survival","volume":"9","author":"Kasraian L","year":"2018","journal-title":"Int J Org Transplant Med"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002468"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.09.026"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2016.1149061"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2016.1149062"},{"key":"e_1_2_10_29_1","unstructured":"European Center for Disease Prevention and Control.Annual Epidemiological Report 2016 \u2013 Healthcare\u2010associated infections acquired in intensive care units.ECDC. 2016. Accessed 30 Sep 2019.https:\/\/ecdc.europa.eu\/en\/publications\u2010data\/healthcare\u2010associated\u2010infections\u2010intensive\u2010care\u2010units\u2010annual\u2010epidemiological\u20100"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010001\u20101143\u2010z"},{"key":"e_1_2_10_31_1","first-page":"152","article-title":"Cytomegalovirus and epstein\u2010barr virus infection in pediatric liver transplants","volume":"3","author":"Frauca E","year":"2009","journal-title":"Trend in Transplant"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_1024_14"}],"updated-by":[{"DOI":"10.1111\/petr.14349","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000}}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.14186","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T09:24:19Z","timestamp":1725441859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.14186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,5]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/petr.14186"],"URL":"https:\/\/doi.org\/10.1111\/petr.14186","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1111\/petr.14349","asserted-by":"object"}]},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,5]]},"assertion":[{"value":"2021-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14186"}}