{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:36:09Z","timestamp":1788554169269,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T00:00:00Z","timestamp":1637452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010915","name":"American Society of Transplant Surgeons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005347","name":"American Association for the Study of Liver Diseases","doi-asserted-by":"publisher","award":["2020 CTORA"],"award-info":[{"award-number":["2020 CTORA"]}],"id":[{"id":"10.13039\/100005347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K08CA245220"],"award-info":[{"award-number":["K08CA245220"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pediatric liver transplant (LT) recipients of maternal living liver donor (LLD) grafts have been reported to experience fewer rejection episodes. However, it is unclear whether this benefit translates to reduction in developing donor\u2010specific antibody (DSA) among maternal\u2010LLD recipients. The aim of this study was to compare immunologic outcomes among maternal\u2010LLD, non\u2010maternal\u2010LLD, and deceased donor liver transplant (DDLT) recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children (\u226418\u00a0years) who underwent LT between 1\/1998 and 12\/2019 at two high\u2010volume LT centers in North America were evaluated. Patients were divided into three groups by type of graft received (maternal\u2010LLD, non\u2010maternal LLD, and DDLT). Clinical variables and outcomes were compared according to each graft type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 450 pediatric primary LT were analyzed: 275 (61.1%) DDLT, 73 (16.2%) maternal\u2010LLD, and 102 (22.6%) non\u2010maternal\u2010LLD. Children receiving LLD grafts were less likely to develop rejection when compared to the DDLT group (DDLT 46.9% vs. maternal\u2010LLD 31.5% vs. non\u2010maternal\u2010LLD 28.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). There was no difference in rejection rates between maternal and non\u2010maternal\u2010LLD recipients. A higher percentage of maternal\u2010LLD recipients were on immunosuppression monotherapy compared to non\u2010maternal\u2010LLD and DDLT recipients (6.7% vs. 1.2 vs. 2.4%, respectively). A subgroup of 68 patients were tested for DSA post\u2010LT. Maternal\u2010LLD recipients were less likely to develop de novo DSA (maternal\u2010LLD 11.8% vs. non\u2010maternal\u2010LLD 19.3% vs. DDLT 43%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.018). None of the maternal\u2010LLD recipients developed antibody\u2010mediated rejection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data support the concept of immunologic benefit of maternal\u2010LLD in pediatric LT, with lower rates of rejection and allosensitization post\u2010LT when compared to DDLT recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14197","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T04:05:18Z","timestamp":1637553918000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Immunologic benefits of maternal living donor allografts in pediatric liver transplantation: fewer rejection episodes and no evidence of de novo allosensitization"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7062-3236","authenticated-orcid":false,"given":"Arianna","family":"Barbetta","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Abdominal Organ Transplant University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenda","family":"Meeberg","sequence":"additional","affiliation":[{"name":"Alberta Transplant Institute  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Rocque","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Abdominal Organ Transplant University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Barhouma","sequence":"additional","affiliation":[{"name":"University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly","family":"Weaver","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Abdominal Organ Transplantation Surgery Children\u2019s Hospital\u2010Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Gilmour","sequence":"additional","affiliation":[{"name":"Alberta Transplant Institute  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Faytrouni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlee","family":"Guttman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Zielsdorf","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Abdominal Organ Transplant University of Southern California  Los Angeles California USA"},{"name":"University of Southern California  Los Angeles California USA"},{"name":"Division of Hepatobiliary and Abdominal Organ Transplantation Surgery Children\u2019s Hospital\u2010Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kambiz","family":"Etesami","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Abdominal Organ Transplant University of Southern California  Los Angeles California USA"},{"name":"University of Southern California  Los Angeles California USA"},{"name":"Division of Hepatobiliary and Abdominal Organ Transplantation Surgery Children\u2019s Hospital\u2010Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Abdominal Organ Transplant University of Southern California  Los Angeles California USA"},{"name":"University of Southern California  Los Angeles California USA"},{"name":"Division of Hepatobiliary and Abdominal Organ Transplantation Surgery Children\u2019s Hospital\u2010Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Yanni","sequence":"additional","affiliation":[{"name":"University of Southern California  Los Angeles California USA"},{"name":"Department of Pediatrics Children\u2019s Hospital\u2010Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Campbell","sequence":"additional","affiliation":[{"name":"Alberta Transplant Institute  Edmonton Alberta Canada"},{"name":"Departemtent of Laboratory Medicine and Pathology University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Alberta Transplant Institute  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-3057","authenticated-orcid":false,"given":"Juliet","family":"Emamaullee","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Abdominal Organ Transplant University of Southern California  Los Angeles California USA"},{"name":"University of Southern California  Los Angeles California USA"},{"name":"Division of Hepatobiliary and Abdominal Organ Transplantation Surgery Children\u2019s Hospital\u2010Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.08.054"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25499"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014\u20103016"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002522"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.10.018"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13318"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000000865"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008\u20101363"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12641"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28681"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.2014"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2007.01799.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01227"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12273"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2011.03895.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13560"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BPOBGYN.2015.08.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000087"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/PETR.14154"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.136"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703146"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqz044"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23788"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12791"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.510250328"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003469"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000001219"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002110"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001094"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890\u2010200109150\u201000031"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3346\/JKMS.2014.29.3.320"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1600\u20106143.2007.02068.X"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13757"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2020.613128"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/LT.23707"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000796"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890\u2010200108150\u201000016"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.31520"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1600\u20106143.2008.02487.X"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164511"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i45.8017"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.14197","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T07:55:27Z","timestamp":1745999727000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.14197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,21]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/petr.14197"],"URL":"https:\/\/doi.org\/10.1111\/petr.14197","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,21]]},"assertion":[{"value":"2021-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14197"}}