{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:03:16Z","timestamp":1788397396776,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Motor skill acquisition plays an important role in physical activity participation and overall social and physical health. Limited studies have examined motor development in children pre\u2010and post\u2010liver transplant (LT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of motor outcomes in children &lt;6\u00a0years old with cholestatic liver disease assessed pre\u2010and 1\u2010year post\u2010isolated LT. Measures include Alberta Infant Motor Scale and Peabody Developmental Motor Scales (gross motor quotient (GMQ), fine motor quotient (FMQ), and total motor quotient (TMQ)). Association of medical variables with motor outcomes was explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants included 33 (58% male) children with diagnoses of biliary atresia (70%), Alagille syndrome (21%), and others (9%). Median age at LT was 10 (IQR 7.0\u201320.5) months. Pre\u2010LT &gt;75% of children were at risk for motor delay (\u226410<jats:sup>th<\/jats:sup> percentile on AIMS\/ \u22651SD below mean GMQ). Post\u2010LT, 52% scored \u22651 SD below the mean GMQ compared with 22% FMQ. Children at risk\/delayed pre\u2010LT had an increased risk of motor delay on GMQ post\u2010LT (odds ratio 11.43, 95% CI 1.12\u2013116.7, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.017). Higher INR pre\u2010LT correlated with lower TMQ post\u2010LT (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.51, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.003). Longer waitlist time correlated with lower FMQ post\u2010LT (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.41, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.03). GMQ post\u2010LT and height z\u2010scores pre\u2010LT (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.46, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.02) and post\u2010LT (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.45, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.01) were positively correlated. There was no correlation with presence of ascites, weight z\u2010score, length of hospitalization, and age at LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Young children have increased risk of motor delay pre\u2010LT, which may persist post\u2010LT. Severity of liver disease and growth delays may impact motor development, highlighting the need for ongoing rehabilitation pre\u2010 and post\u2010LT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14200","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T11:17:54Z","timestamp":1638875874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Motor outcomes in young children pre\u2010and one\u2010year post\u2010liver transplant"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0765-5144","authenticated-orcid":false,"given":"Catherine","family":"Patterson","sequence":"first","affiliation":[{"name":"Rehabilitation Medicine The Hospital for Sick Children  Toronto ON Canada"},{"name":"Transplant and Regenerative Medicine The Hospital for Sick Children  Toronto ON Canada"},{"name":"University of Toronto  Toronto ON 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for Sick Children  Toronto ON Canada"},{"name":"University of Toronto  Toronto ON Canada"},{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition The Hospital for Sick Children  Toronto ON 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