{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:31:03Z","timestamp":1792186263799,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Surgical repair for patients with congenital heart disease (CHD) often incorporates homograft tissue or other foreign material that can lead to allosensitization. We sought to identify the relationship between pre\u2010sensitization prior to heart transplant and exposure to homograft tissue in CHD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective chart review of all CHD patients who underwent heart transplant at a major pediatric transplant center between 1\/1\/2011\u20103\/31\/18. Operative records determined use of homograft tissue or foreign material. Panel reactive antibody (PRA) and Luminex\n                      <jats:sup>TM<\/jats:sup>\n                      single\u2010antigen bead (SAB) testing results were reviewed. Statistical analysis determined odds of pre\u2010sensitization in patients exposed to homograft tissue.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010six CHD patients underwent transplant during the review period. Thirteen patients (23%) were pre\u2010sensitized by PRA&gt;10%. By SAB testing, 33 patients (59%) developed any anti\u2010HLA antibody &gt;0\u00a0MFI, 30 patients (54%) &gt;2000\u00a0MFI, and 19 patients (34%) &gt;6000\u00a0MFI. Patients with homografts were more likely to be pre\u2010sensitized by PRA (OR\u00a0=\u00a07.31,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.007), and to have developed any anti\u2010HLA antibody at various levels, &gt;0 (OR\u00a0=\u00a04.52,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.034), &gt;2000 (OR\u00a0=\u00a08.59,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.003), and &gt;6000 (OR\u00a0=\u00a08.50,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.004). Of patients with homografts, those pre\u2010sensitized by PRA had longer exposure times (9.80 vs 4.96\u00a0years,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.025). There was no difference in exposure time with relation to pre\u2010sensitization by SAB testing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Previous exposure to homograft tissue appears to increase the odds of pre\u2010sensitization by either the PRA or SAB testing. Longer exposure time to homograft tissue prior to transplant is associated with increased pre\u2010sensitization at transplant as determined by PRA, though not by SAB testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/petr.14201","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T05:34:50Z","timestamp":1639114490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association between homograft tissue exposure and allosensitization prior to heart transplant in patients with congenital heart disease"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-1996","authenticated-orcid":false,"given":"Denis J.","family":"Donovan","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology New York\u2010Presbyterian Morgan Stanley Children\u2019s Hospital Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5491-8085","authenticated-orcid":false,"given":"Marc E.","family":"Richmond","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology New York\u2010Presbyterian Morgan Stanley Children\u2019s Hospital Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emile A.","family":"Bacha","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiac Surgery New York\u2010Presbyterian Morgan Stanley Children\u2019s Hospital Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda J.","family":"Addonizio","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology New York\u2010Presbyterian Morgan Stanley Children\u2019s Hospital Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren A.","family":"Zuckerman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology New York\u2010Presbyterian Morgan Stanley Children\u2019s Hospital Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002572"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a44206"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200301150-00008"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000281918.51138.3f"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00425.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000180564.14050.49"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01446.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.08.008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13259"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/376027"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)80328-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(00)70188-7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.917232"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.07.052"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2004.12.033"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.12.009"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14695"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000598"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.02.015"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14876"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.01.401"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.03.015"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.14077"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/2150135117723916"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2012.01885.x"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.14201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.14201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T03:55:53Z","timestamp":1745985353000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.14201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,10]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/petr.14201"],"URL":"https:\/\/doi.org\/10.1111\/petr.14201","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,10]]},"assertion":[{"value":"2021-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14201"}}