{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:41:18Z","timestamp":1753879278380,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Valvular disease in pediatric and young adult donor hearts may be a relative contraindication to graft use. Outcomes following the use of donor hearts with bicuspid aortic valve (BAV) have not been previously reported in children. We describe 4 cases of pediatric heart transplantation (HTx) utilizing a donor heart with a BAV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case series<\/jats:title><jats:p>Of the 469 HTx included in this study, 4 utilized a donor heart with a BAV. All recipients were female; median age was 11\u00a0years (range 0.3 to 19\u00a0years). In all cases, the BAV was not discovered until after HTx. All donors were less than 30\u00a0years old. The patients were followed for a median of 6\u00a0years (range 2 to 9\u00a0years) with all patients alive at last follow\u2010up. Two patients have transitioned to adult care, and 2 patients continue to follow in our clinic. In follow\u2010up, no patient has required an aortic valve intervention or had infective endocarditis. At last review, no patient had greater than mild aortic insufficiency or more than mild aortic stenosis. Three patients developed mild\u2010to\u2010moderate left ventricular hypertrophy in the first year post\u2010transplant that improved over time. One patient experienced a peri\u2010operative embolic stroke at time of transplant unrelated to the BAV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>On short\u2010 and intermediate\u2010term follow\u2010up, pediatric and young adult donor hearts with BAV demonstrated acceptable graft longevity and valvular function. A functionally normal BAV in a pediatric heart transplant donor should not be a contraindication to organ acceptance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14212","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T06:04:47Z","timestamp":1639807487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes following use of pediatric and young adult donor hearts with bicuspid aortic valves: A single\u2010center case series"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4205-6363","authenticated-orcid":false,"given":"Patrick","family":"Day","sequence":"first","affiliation":[{"name":"Department of Pediatrics Texas Children\u2019s Hospital Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Hope","sequence":"additional","affiliation":[{"name":"Lillie Frank Abercrombie Division of Pediatric Cardiology Department of Pediatrics Texas Children\u2019s Hospital Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kriti","family":"Puri","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine Department of Pediatrics Texas Children\u2019s Hospital Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9539-6252","authenticated-orcid":false,"given":"Joseph","family":"Spinner","sequence":"additional","affiliation":[{"name":"Lillie Frank Abercrombie Division of Pediatric Cardiology Department of Pediatrics Texas Children\u2019s Hospital Baylor College of Medicine  Houston Texas 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