{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:39:47Z","timestamp":1793277587044,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on sex\u2010based disparities in children with kidney failure and outcomes after kidney transplantation are relatively sparse. This study examined the association between sex differences and the odds of receiving a pre\u2010emptive living donor kidney transplantation, and post\u2010transplant outcomes in children and adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied all patients (aged &lt;20\u00a0years) who commenced kidney replacement therapy (KRT) between 2002 and 2017 using data from the ANZDATA Registry. Factors associated with graft loss and acute rejection after transplantation were assessed using multivariable Cox regression model. Differences in the odds of receiving a pre\u2010emptive live donor transplant between sexes were assessed using adjusted logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 757 children transplanted during the study period, 497 (65.7%) received a live donor kidney (163, 21.5% pre\u2010emptive). In total, 168 (22.2%) patients experienced graft loss and 213 (28.1%) patients experienced a first episode of acute rejection during the median follow\u2010up period of 6.9\u00a0years (IQR 3.5\u201311.5\u00a0years). There were no differences in the rates of graft loss or acute rejection by sex. Compared with boys, the adjusted hazard ratios (aHR) (95% confidence interval) for graft loss and acute rejection in girls were 0.97 (0.71\u20131.33) and 1.09 (0.82\u20131.44), respectively. Among children who received living donor kidney transplants, there were no sex differences in the odds of receiving a pre\u2010emptive transplant (adjusted odds ratio (aOR) 0.90 (95% CI 0.56\u20131.45)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No sex differences were observed in the odds of receiving a pre\u2010emptive living donor kidney transplant or outcomes after kidney transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14224","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T07:49:59Z","timestamp":1641887399000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sex differences in the likelihood of pre\u2010emptive living donor kidney transplantation, and outcomes after kidney transplantation in children and adolescents"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3706-7375","authenticated-orcid":false,"given":"Rowena","family":"Lalji","sequence":"first","affiliation":[{"name":"Centre for Kidney Disease Research University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Nephrology Queensland Children's Hospital  Brisbane Queensland Australia"},{"name":"Metro South and Integrated Nephrology and Transplant Services (MINTS) Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5106-3712","authenticated-orcid":false,"given":"Anna","family":"Francis","sequence":"additional","affiliation":[{"name":"Centre for Kidney Disease Research University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Nephrology Queensland Children's Hospital  Brisbane Queensland Australia"},{"name":"Metro South and Integrated Nephrology and Transplant Services (MINTS) Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Blazek","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health University of Sydney  Sydney New South Wales Australia"},{"name":"Centre for Kidney Research The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-2516","authenticated-orcid":false,"given":"Armando","family":"Teixeira\u2010Pinto","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health University of Sydney  Sydney New South Wales Australia"},{"name":"Centre for Kidney Research The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-7269","authenticated-orcid":false,"given":"Germaine","family":"Wong","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health University of Sydney  Sydney New South Wales Australia"},{"name":"Centre for Kidney Research The Children's Hospital at Westmead  Sydney New South Wales Australia"},{"name":"Centre for Transplant and Renal Research Westmead Institute for Medical Research University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5491-3460","authenticated-orcid":false,"given":"David W.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Centre for Kidney Disease Research University of Queensland  Brisbane Queensland Australia"},{"name":"Metro South and Integrated Nephrology and Transplant Services (MINTS) Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"Translational Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja18.00304"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016121380"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijn.IJN_81_18"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241556"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31825d156a"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.12.004"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12003"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13484"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000699416.23970.a8"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.04.058"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.07.019"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010020\u201002156\u20102"},{"key":"e_1_2_12_14_1","unstructured":"RStudio: 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