{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T16:15:03Z","timestamp":1771604103949,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The UK Renal Registry is responsible for the national collection and reporting of data on all children receiving long\u2010term kidney replacement therapy [KRT], including kidney transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All 13 UK pediatric nephrology centers contributed to providing individual patient data from the pediatric population incident to and prevalent to KRT as per the date 31 December 2018. Data for children aged 16\u2013&lt;18\u00a0years were presented separately as some were managed under adult care settings with different methods of data collection. Demographics and biochemical data, including kidney function and prevalence of cardiovascular risk factors [hypertension, hypercholesterolemia, BMI] were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight hundred and twenty\u2010six children (65.4 per million age\u2010related population [pmarp]) and 199 young people (139.4pmarp) in the United Kingdom were prevalent to KRT on 31 December 2018. Overall, the incidence of KRT during 2018 was 9.1\u00a0pmarp and 12.6\u00a0pmarp in children and young people, respectively. Congenital anomalies of the kidney and urinary tract (CAKUT) were the most prevalent primary diagnoses (52%). Living and deceased donor transplantation was the most common treatment modality (78%). Patients on dialysis had lower age standardized mean height and weight ranges recorded in comparison to transplant patients [median height z score \u22121.8 vs. \u22121.1]. 73.1% patients had one or more cardiovascular disease risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights increasing prevalence of hemodialysis and living donor transplantation as modalities for KRT. Of those incident to KRT, the highest patient survival was seen among 8\u201312\u00a0years and lowest &lt;2\u00a0years. Moreover, there was a demographic shift from Caucasian toward Asian\/other ethnicity and from CAKUT to other primary kidney diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/petr.14232","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T06:19:15Z","timestamp":1643091555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Increasing trends in hemodialysis and living donor kidney transplantation for children and young people in the United Kingdom"],"prefix":"10.1111","volume":"26","author":[{"given":"Nadeesha Lakmal","family":"Mudalige","sequence":"first","affiliation":[{"name":"NIHR Great Ormond Street Hospital Biomedical Research Centre University College London Great Ormond Street Institute of Child Health  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3571-1684","authenticated-orcid":false,"given":"Kristi","family":"Sun","sequence":"additional","affiliation":[{"name":"NIHR Great Ormond Street Hospital Biomedical Research Centre University College London Great Ormond Street Institute of Child Health  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Plumb","sequence":"additional","affiliation":[{"name":"UK Renal Registry  Bristol UK"},{"name":"Population Health Sciences University of Bristol Medical School  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Casula","sequence":"additional","affiliation":[{"name":"UK Renal Registry  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharine\u00a0M.","family":"Evans","sequence":"additional","affiliation":[{"name":"UK Renal Registry  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Inward","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology University Hospitals Bristol NHS Foundation Trust  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9850-8352","authenticated-orcid":false,"given":"Stephen D.","family":"Marks","sequence":"additional","affiliation":[{"name":"NIHR Great Ormond Street Hospital Biomedical Research Centre University College London Great Ormond Street Institute of Child Health  London UK"},{"name":"Department of Pediatric Nephrology Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"NHSBT.Kidney transplantation: deceased donor organ allocation (POL 186\/10).https:\/\/nhsbtdbe.blob.core.windows.net\/umbraco\u2010assets\u2010corp\/16915\/kidney\u2010allocation\u2010policy\u2010pol186.pdf. Published 2020."},{"key":"e_1_2_10_3_1","unstructured":"Association TR.Guidelines and commentaries.https:\/\/renal.org\/health\u2010professionals\/guidelines\/guidelines\u2010commentaries. Accessed December 5 2020."},{"key":"e_1_2_10_4_1","unstructured":"NHS Blood and Transplant.ANNUAL REPORT ON KIDNEY TRANSPLANTATION REPORT FOR 2017\/2018.https:\/\/nhsbtdbe.blob.core.windows.net\/umbraco\u2010assets\u2010corp\/12256\/nhsbt\u2010kidney\u2010transplantation\u2010annual\u2010report\u20102017\u20102018.pdf. 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